中国医药科学Issue(9)：17-19,98,4.
循环肿瘤细胞与鼻咽癌临床病理参数的相关性研究
Correlation of circulating tumor cells with clinicopathological parameters in patients with nasopharyngeal carcinoma
伍勇 1翁成荫 1方喜生 1曹小飞 1李宝秀 1毛海波 1刘霞 1关明媚 1刘国龙1
作者信息
- 1. 广州医科大学附属广州市第一人民医院肿瘤科，广东广州 510180
- 折叠
摘要
Abstract
Objective To analyze the correlation of circulating tumor cells(CTCs)with clinicopathological parameters in patients with nasopharyngeal carcinoma(NPC),and explore its clinical significance. Methods CTCs were detected in 63 non-treated NPC patients and 20 normal people using CyttelBio CTC detection technology.The differential expression of CTCs and relationship between CTCs and clinicopathological parameters were analyzed. Results The positive rate of CTCs in NPC patients was 55.6%,while it is 0 in normal people,and the difference was statistically significant(x2=19.213,P < 0.05).In M0 and M1 NPC patients,the positive rate of CTCs was 48.1% and 90.9% respectively,with significant difference (x2=6.746,P < 0.05).In NPC patients with negativeEBV-DNA,the positive rate of CTCs was 45.5%,while in patients withpositive EBV-DNA,the rate was 78.9%,and the difference was statistically significant(x2=6.029,P < 0.05).In groups with differentgender,age,histological type,T stage,N stage,overall stage or VCA-IgA,the positive rates of CTCs had no significant difference. Conclusion CTCs are closely correlated with NPC metastasis and EBV-DNA,and can be used to evaluate NPC.关键词
循环肿瘤细胞/鼻咽癌/临床病理参数Key words
Circulating tumor cells/Nasopharyngeal carcinoma/Clinicopathological parameters分类
医药卫生引用本文复制引用
伍勇,翁成荫,方喜生,曹小飞,李宝秀,毛海波,刘霞,关明媚,刘国龙..循环肿瘤细胞与鼻咽癌临床病理参数的相关性研究[J].中国医药科学,2015,(9):17-19,98,4.
