摘要
Abstract
Objective To study the contents of three kinds of tumor marker in bronchoalveolarlavage fluid and its value in diagnosis and assessment oflung cancer. Methods 80 cases of lung cancer patients in our hospital from 2013 May to 2014 May were enrolled in observation group,80 cases of benign lung lesions patients over the same period were enrolled in control group.Bronchoalveolar lavage were collected,mRNA content of tumor marker were detected by fluorescence quantitative PCR method,protein content of tumor marker were detected by Elisa method. Results (1)Cyfra21-1,SCC,TSGF content in bronchoalveolar lavage fluid of different TNM stage were different;as TNM stage increase,Cyfra21-1,SCC,TSGF content in BALF increase,difference had statistical significance(P < 0.05);(2)Cyfra21-1,SCC,TSGF content in serum of TNM Ⅰ stage and TNM Ⅱ stage were no different;Cyfra21-1,SCC,TSGF content in serum of TNM Ⅲ stage and TNM Ⅳ were different,difference had statistical significance(P < 0.05); Conclusion tumor markers content in serum in lung cancer patients increase from TNM III stage,Cyfra21-1,SCC,TSGF content in bronchoalveolar lavage fluid increase from TNM Ⅰ stage,tumor markers content detection in BALF is helpful for early diagnosis of lung cancer.关键词
肺癌/支气管肺泡灌洗液/肿瘤相关抗原细胞角蛋白19片段抗原21-1/肿瘤特异性生长因子/鳞状细胞癌相关抗原Key words
Lung cancer/Bronchoalveolar lavage fluid Cyfra21-1/SCC/TSGF分类
医药卫生
