中国医院用药评价与分析Issue(6)：501-502,503,3.
乌司他丁对慢性阻塞性肺疾病患者炎症因子及临床疗效的影响
Effect of Ulinastatin on the Inflammatory Factors and Clinical Efficacy in Patients with Chronic Obstruc-tive Pulmonary Disease
白士先1
作者信息
- 1. 青州市益都中心医院重症医学科，山东青州 262500
- 折叠
摘要
Abstract
OBJECTIVE:To investigate the regulatory effects of ulinastatin on tumor necrosis factor-α(TNF-α)and interleukin 6(IL-6)and its clinical efficacy in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD)undergoing invasive mechanical ventilation. METHODS:A total of 64 patients with acute exacerbation of COPD admitted to our hospital from Jan. 2012 to Dec. 2013 were randomly assigned to receive either routine therapy alone(control group)or routine therapy plus Ulina-statin (trial group) of 60 each. Plasma levels of TNF-α and IL-6 were determined by ELISA and the inflammatory factors in both groups,length of hospital stay,mechanical ventilation time,the number of complications and treatment costs were recorded. RE-SULTS:All patients weaned successfully from the mechanical ventilator and discharged from hospital with recovery after treatment. Serum levels of TNF-α and IL-6 in both groups declined significantly after treatment,much as in the treatment group,showing sta-tistically significant differences between two groups (P<0.05);the length of hospital stay,the mechanical ventilation time,the number of complications and the treatment costs were all lower in the trial group than in the control group (P<0.05). CONCLU-SIONS:Ulinastatin can relieve ventilation it is of good clinical efficacy and economic efficacy inflammatory response,shorten treat-ment time,improve short-term outcome in patients with COPD receiving invasive mechanical ventilation. It is of good clinical and economic efficacy.关键词
乌司他丁/慢性阻塞性肺疾病/临床疗效Key words
Ulinastatin/Chronic obstructive pulmonary disease/Clinical efficacy分类
医药卫生引用本文复制引用
白士先..乌司他丁对慢性阻塞性肺疾病患者炎症因子及临床疗效的影响[J].中国医院用药评价与分析,2014,(6):501-502,503,3.
