中国医院用药评价与分析Issue(7)：596-598,3.
莫沙必利联合奥美拉唑治疗胃食管反流病的临床研究
Clinical Trial of Mosapride Combined with Omeprazole in Treatment of Gastroesophageal Reflux Disease
吕双丛 1张守元2
作者信息
- 1. 解放军第264医院药剂科，太原 030000
- 2. 山东省鲁南工程技术研究院管理中心，山东济宁 272000
- 折叠
摘要
Abstract
OBJECTIVE:To evaluate the efficacy and safety of mosapride combined with omeprazole in treatment of gastro-esophageal reflux disease. METHODS:80 patients with gastroesophageal reflux disease were randomly divided into a treatment group(n=40)and control group(n=40). Treatment group was given omeprazole(20 mg,bid)plus mosapride(5 mg,tid)while the control group was given mosapride(5 mg,tid)for 8 weeks. After treatment completion,the rate of patients showing relief of common symptoms and the adverse drug reactions were compared between the two groups;and the effective rate was evaluated by gastroscopy. RESULTS:After 8-week treatment,the patients in the treatment group showed high rate of relief of common symp-toms including heartburn,sour regurgitation,chest pain and other symptoms than in the control group on average (85.7% vs. 63.3%,P<0.05),and the effective rate evaluated by gastroscopy was also higher than in the control group(77.5% vs. 52.5%,P<0.05). During treatment,all of the patients were well tolerated,with no serious adverse reactions noted. CONCLUSIONS:Mo-sapride combined with omeprazole resulted in high rate of symptom relief and high effective rate gastroscopically with good clinical efficacy and safety in patients with gastroesophageal reflux disease.关键词
胃食管反流病/莫沙必利/奥美拉唑Key words
Gastroesophageal reflux disease/Mosapride/Omeprazole分类
医药卫生引用本文复制引用
吕双丛,张守元..莫沙必利联合奥美拉唑治疗胃食管反流病的临床研究[J].中国医院用药评价与分析,2014,(7):596-598,3.
