中国医院用药评价与分析Issue(9)：783-785,3.DOI:10.14009/j.issn.1672-2124.2014.09.006
根除幽门螺杆菌的三联方案中3种质子泵抑制剂的成本-效果分析
Cost-effectiveness Analysis of Proton Pump Inhibitors in Three Triple Therapies for Helicobacter Pylori Erad-ication
陈侃 1蔡忠捷1
作者信息
- 1. 宁德市闽东医院药剂科，福建福安 355000
- 折叠
摘要
Abstract
OBJECTIVE:To conduct pharmacoeconomic evaluation on proton pump inhibitors in three triple therapies for Heli-cobacter pylori(Hp)eradication for clinical reference of drug use. METHODS:Between September 2012 and September 2013,a to-tal of 106 peptic ulcer patients with Hp positive were randomly assigned to receive omeprazole plus ornidazole and clarithromycin (group A),rabeprazole plus ornidazole and clarithromycin (group B) or ilaprazole plus ornidazole and clarithromycin (group C) for 10 days. After drug withdrawal for 4 weeks,a cost-effectiveness analysis was performed for economic evaluation. RESULTS:The total effective rates of the three groups were 88.57%,91.43%and 91.57%respectively,showing no statistically significant dif-ferences between groups (P>0.05);the cost-effectiveness ratios in the three groups were 2.59,2.51 and 8.88 respectively. CON-CLUSIONS:From the perspective of pharmacoeconomics,the triple therapy with omeprazole is as cost-effective as the triple thera-py with rabeprazole but better than the triple therapy with ilaprazole.关键词
质子泵抑制剂/幽门螺杆菌/消化性溃疡/成本-效果分析Key words
Proton pump inhibitor/Helicobacter pylori/Peptic ulcer/Cost-effectiveness analysis分类
医药卫生引用本文复制引用
陈侃,蔡忠捷..根除幽门螺杆菌的三联方案中3种质子泵抑制剂的成本-效果分析[J].中国医院用药评价与分析,2014,(9):783-785,3.
