中国医院用药评价与分析Issue(10)：884-886,887,4.DOI:10.14009/j.issn.1672-2124.2014.10.009
奥拉西坦治疗缺血性脑卒中后认知功能障碍的临床观察
Clinical Efficacy of Oxiracetam for Cognitive Dysfunction in Patient with Cerebral Ischemic Stroke
李小燕1
作者信息
- 1. 濮阳市油田总医院药剂科，河南濮阳 457001
- 折叠
摘要
Abstract
OBJECTIVE:To evaluate the therapeutic efficacy and safety of Oxiracetam for cognitive dysfunction in patients with cerebral ischemic stroke. METHODS:Between Nov. 2011 and Oct. 2013, a total of 102 patients with cognitive dysfunction following development of cerebral ischemic stroke in Puyang Oil Field General Hospital were randomly assigned to two groups of 51 each. The control group received add-on oral Piracetam Tablets 1 600 mg/time tid and the treatment group received add-on Oxiracetam Capsules(800 mg/time) bid. After three course of treatment (4 weeks in one course of treatment), Montreal Cognitive Assessment(MoCA), Activity of Daily Living Scale(ADL) and P300PL(latency period) in the two groups were recorded. RESULTS:The total effective rate in the treatment group was significantly higher than in the control group(84�31% vs. 64�70%), and the difference between the 2 groups was statistically significant(χ2 =4�18, P<0�05);compared with before treatment, the MoCA score and ADL score in both groups were significantly improved after treatment, with treatment group showing better improvement than in the control group(P<0�05); P300 PL in N2 and P3 latency and amplitude of P3 wave in both groups significantly improved compared with before treatment(P<0�05), and the differences between the two groups after treatment were statistically significant ( P<0�05 ) . No severe ADR was found for both groups. CONCLUSIONS:Oxiracetam is safe and effective yet it is more effective than Piracetam in the treatment of cognitive dysfunction in patients with cerebral ischemic stroke.关键词
奥拉西坦/缺血性脑卒中/认知功能障碍/疗效观察Key words
Oxiracetam/Cerebral schemic stroke/Cognitive dysfunction/Effective observation分类
医药卫生引用本文复制引用
李小燕..奥拉西坦治疗缺血性脑卒中后认知功能障碍的临床观察[J].中国医院用药评价与分析,2014,(10):884-886,887,4.
