中国医院用药评价与分析Issue(11)：979-981,3.DOI:10.14009/j.issn.1672-2124.2014.11.006
银花抗病毒合剂的制备与质量控制
Preparation and Quality Control of Yinhua Antiviral Mixture
祝文兵 1龙荣 1彭芳玲 1田静1
作者信息
- 1. 湖南省儿童医院药剂科，长沙 410007
- 折叠
摘要
Abstract
OBJECTIVE:To prepare Yinhua antiviral mixture and establish its quality control method.METHODS:The Yinhuak antiviral mixture was prepared using radix isatidis, flos lonicerae japonicae, radix scutellariae and forsythia suspensa ( thunb.) vahl etc.Flos lonicerae japonicae and coptis chinensis franch.in the mixture were identified qualitatively by TLC.The contents of chlorogenic acid and baicalin were determined by HPLC.RESULTS:The Yinhua antiviral mixture was brown solution.The clear specific spots of Flos lonicerae japonicae and coptis chinensis franch were noted in TLC identification.The same fluorescent spots were noted for the sample at the position corresponding to that of the reference substance.The linear range of chlorogenic acid was 36.0-360.0 ng ( r=0.999 6, n=6) and that of baicalin was 36.8-368.0 ng (r =0.999 9, n =6), with average recovery rates of 101.96% and 101.01%, respectively and RSD of 1.38%and 1.88%, respectively(n=5).CONCLUSIONS:The preparing technique of Yinhua antiviral mixture is simple and the method for its quality control is stable, accurate and reproducible.关键词
银花抗病毒合剂/绿原酸/黄芩苷/高效液相色谱法/质量控制Key words
Yinhua antiviral mixture/Chlorogenic acid/Baicalin/HPLC/Quality control分类
医药卫生引用本文复制引用
祝文兵,龙荣,彭芳玲,田静..银花抗病毒合剂的制备与质量控制[J].中国医院用药评价与分析,2014,(11):979-981,3.
