中国医院用药评价与分析Issue(11)：985-987,3.DOI:10.14009/j.issn.1672-2124.2014.11.008
枸橼酸咖啡因与氨茶碱治疗早产儿呼吸暂停的疗效比较
Efficacy of Citrated Caffeine versus Aminophylline for Apnea of Prematurity
金小兰 1谭玮 1丁香平 1刘冲冲 1罗勤 1周锦1
作者信息
- 1. 龙 江西省妇幼保健院新生儿科，南昌 330006
- 折叠
摘要
Abstract
OBJECTIVE:To evaluate the efficacy of caffeine citrate for apnea of prematurity.METHODS:A total of 66 premature infants at gestational age of 26 to 32 weeks with apnea attack of at least one time within 24 hrs or longer after birth were enrolled, with 33 assigned to observation group treated with citrated caffeine at load dosage of 20 mg/kg ( caffeine base 10 mg/kg) by intravenous infusion (30 min) , 24 hrs later, then the patients were administered intravenously or orally with citrated caffeine at dosage of 5 mg/(kg· d)[caffeine base 2.5 mg/(kg· d)], another 33 were assigned to control group treated intravenously with aminophylline at initial dose of 5.0 mg/kg, 8-12 hours later, these patients were treated with aminophylline at dosage of 2.0 mg/kg bid for 5 days.RESULTS: There was more reduction in the incidence of apnea in the observation group than in the control group, but the differences between the two groups were not statistically significant (P>0.05).CONCLUSIONS: Caffeine citrate administered intravenously at a dose of 20 mg/kg ( equivalent to caffeine base 10 mg/kg) followed by intravenous or oral administration at dosage of 5 mg/( kg· d) [ equivalent to caffeine base base 2.5 mg/( kg· d) ] for 5 days is as effective as theophylline for apnea of prematurity in the premature infants born after gestation of 26 to 32 weeks.关键词
枸橼酸咖啡因/早产儿呼吸暂停/氨茶碱Key words
Caffeine citrate/Apnea of prematurity/Aminophylline分类
医药卫生引用本文复制引用
金小兰,谭玮,丁香平,刘冲冲,罗勤,周锦..枸橼酸咖啡因与氨茶碱治疗早产儿呼吸暂停的疗效比较[J].中国医院用药评价与分析,2014,(11):985-987,3.
