中国医院用药评价与分析Issue(11)：996-997,998,3.DOI:10.14009/j.issn.1672-2124.2014.11.012
乌司他丁与奥曲肽联合治疗重症急性胰腺炎的疗效观察
Efficacy of Ulinastatin plus Octreotide for Severe Acute Pancreatitis
尚卫明1
作者信息
- 1. 丹江口市第一医院急诊科，湖北丹江口 442700
- 折叠
摘要
Abstract
OBJECTIVE:To evaluate the efficacy of ulinastatin plus octreotide for severe acute pancreatitis ( SAP) .METHODS:A total of 125 SAP patients were randomly divided into control group ( n=62 ) and observation group ( n=63 ) with control group treated with octreotide and the observation group with ulinastatin plus octreotide. The total effective rate, time to relief of clinical symptoms, positive rates of serum amylase and urine amylase, CRP and inflammatory factors and adverse drug reaction were compared between the two groups. RESULTS: After treatment, the time to relief of abdominal pain, subsiding time of pancreatic edema and the time to discharge were significantly less in the observation group than in the control group ( P <0.05 ); the total effective rate in the observation group was significantly higher than in the control group ( P<0.05 ) and the positive rates of serum amylase and urine amylase in the observation group were significantly lower than in the control group (P<0.05);furthermore, the indicators such as CRP, IL-10, IL-15 and TNF-αin the observation group were all better than in the control group (P<0.05).Adverse drug reaction was noted in neither group.CONCLUSIONS: Ulinastatin plus octreotide showed remarkable efficacy for severe acute pancreatitis, which thus is worthy of popularization in clinical application.关键词
奥曲肽/乌司他丁/重症急性胰腺炎Key words
Ulinastatin/Octreotide/Severe acute pancreatitis分类
医药卫生引用本文复制引用
尚卫明..乌司他丁与奥曲肽联合治疗重症急性胰腺炎的疗效观察[J].中国医院用药评价与分析,2014,(11):996-997,998,3.
