中国医院用药评价与分析Issue(12)：1067-1070,4.DOI:10�14009/j.issn.1672-2124.2014.12.004
雷公藤多苷对实验性自身免疫性重症肌无力大鼠的治疗作用研究Δ
Therapeutic Efficacy of Tripterygium Glycosides for experimental autoimmune myasthenia gravis in Rats:An Experimental StudyΔ
摘要
Abstract
OBJECTIVE:To explore the therapeutic efficacy of tripterygium glycosides ( TG ) for experimental autoimmune myasthenia gravis( EAMG) . METHODS:The EAMG rat model was established. The therapeutic efficacy of tripterygium glycosides for EAMG in rats was evaluated by using Lennon scoring and body mass monitoring; the mRNA expression of the BV gene in thymus and in peripheral blood mononuclear cells T⁃cell receptor( T⁃cell receptor, TCR) were detected by quantitative real⁃time polymerase chain reaction ( RT⁃PCR ) in complete freund�s adjuvant group,EAMG model group and tripterygium glycosides treatment group. RESULTS: The use of tripterygium glycosides resulted in improvement of the clinical symptoms of myasthenia gravis, reduction of LennonLA score but increase of body mass. The TCR BV gene expression profiles in EAMG rat model presented offset, while the message RNA ( mRNA) expression in tripterygium glycosides group showed reduction ( P <0�05 ) . CONCLUSIONS:Treatment of EAMG with tripterygium glycosides effectively alleviated EAMG symptoms, prevent offset of TCR BV gene and reduce the activities of the specificity⁃activated antigen⁃reactive T cells.关键词
雷公藤多苷/实验性自身免疫性重症肌无力/T细胞受体Key words
Tripterygium glycosides/Experimental autoimmune myasthenia gravis/T cell receptor分类
医药卫生引用本文复制引用
刘兰涛,郭尚福,郎志芳,初彦辉,王洪伟,徐玉东..雷公藤多苷对实验性自身免疫性重症肌无力大鼠的治疗作用研究Δ[J].中国医院用药评价与分析,2014,(12):1067-1070,4.基金项目
黑龙江省教育厅科学技术研究项目 （）
