摘要
Abstract
OBJECTIVE:To investigate the drug resistance and clinical characteristics of the 150 strain of Burkholderia cepacia isolated from the patients in The Second Hospital of Shanxi Medical University .METHODS:The susceptibility of Burkholderia cepacia strains to five kinds of antimicrobial agents was detected by disk diffusion method, and the data of the patients with positive Burkholderia cepacia strains were analyzed retrospectively . RESULTS:Of the total 150 strains of Burkholderia cepacia ,126 strains were isolated from sputum specimens , 6 blood specimens , 2 central venous catheter specimens , 10 drainage fluid and secretion , 2 urine specimen , 2 feces and 2 throat swab specimen.The sensitive rates of Burkholderia cepacia to meropenem , imipenem, selectrintrimesulf, minocycline and ceftazidime were 63.22%, 14.3%, 75.82%, 65.47%and 76.00%, respectively .The 150 strains of Burkholderia cepacia were isolated from a total of 112 patients , and these patients had at least two underlying diseases, with 89 patients(87.8%) complicated with other bacterial infection , 92(86.6%) indwelling catheter, and all these patients used antimicrobial drugs before culture of Burkholderia cepacia , among them , 61 patients used Carbapenems .The average length of hospital stay for these patients in whom Burkholderia cepacia were isolated was (31.38 ±24.56) days.Among the 112 cases, 17 cases were cured (15.18%), 65 took a turn for the better (58.04%), 22 cases died(19.64%) and 8 cases had gave up treatment(7.14%).CONCLUSIONS:The major risk factors for Burkholderia cepacia infection includes underlying diseases , long hospital stay , indwelling catheters , selecting high level of antimicrobial drugs and prolonged duration of medication .Cotrimoxazole and ceftazidime should be used as first choice in clinical treatment of Burkholderia cepacia infection .关键词
洋葱伯克霍尔德菌/抗菌药物/耐药性/危险因素Key words
Burkholderia cepacia/Antibiotics/Drug resistance/Risk factor分类
医药卫生
