中国医院用药评价与分析Issue(4)：472-475,4.DOI:10.14009/j.issn.1672-2124.2015.04.013
普卢利沙星片与盐酸左氧氟沙星片治疗急性细菌性感染对比研究
Prulifloxacin Tablet vs.Levofloxacin Hydrochloride Tablet in the Treatment of Acute Bacterial Infection:A Randomized Controlled Clinical Trial
李玮 1刘洋 1郑学海 2赵克勤3
作者信息
- 1. 湖北省红安县人民医院 药剂科，湖北红安 438400
- 2. 武汉市中心医院药学部，湖北武汉 430014
- 3. 湖北省红安县人民医院 呼吸内科，湖北红安 438400
- 折叠
摘要
Abstract
OBJECTIVE:To evaluate the clinical efficacy and safety of prulifloxacin tablet vs.levofloxacin hydrochloride tablet for acute respiratory tract or urinary tract infection.METHODS: By a randomized controlled clinical trial, the patients with acute bacterial infection were randomly assigned to either trial group administered orally with Prulifloxacin tablets ( at a dosage of 0.2 g twice daily for 7 to 14 days) or control group administered orally with levofloxacin hydrochloride tablet ( at a dosage of 0.2 g twice daily for 7 to 14 days) .RESULTS:A total of 223 patients were enrolled, of whom, 210 patients were assigned to either trial group ( n=104) or control group ( n=106) ( the others were lost follow-up or excluded from our study) .At treatment completion, the cure rate and response rate were 70.19%and 91.35% in trial group, as compared with 71.70% and 89.62% in the control group; the bacterial clearance rates in the trial group and the control group were 86.27%and 88.68%, respectively, with all of the above results showing no statistical differences between the two groups ( P >0.05 ) .Adverse drug reactions including diarrhea, skin rash and stomachache were noted in both groups, which occurred in 4.81% of the trial group vs. 6.60%of the control group, showing statistical difference between the two groups ( P >0.05 ) .CONCLUSION:Prulifloxacin tablet is similar to levofloxacin hydrochloride tablet in that both have remarkable antibacterial activity, and which was safe and effective in the treatment of acute bacterial infection of respiratory or urinary tract, furthermore it is cost-effective in the treatment of acute bacterial infection.关键词
普卢利沙星片/盐酸左氧氟沙星片/急性细菌性感染/随机对照试验Key words
Prulifloxacin tablet/Levofloxacin hydrochloride tablet/Acute bacterial infection/Randomized controlled trial分类
医药卫生引用本文复制引用
李玮,刘洋,郑学海,赵克勤..普卢利沙星片与盐酸左氧氟沙星片治疗急性细菌性感染对比研究[J].中国医院用药评价与分析,2015,(4):472-475,4.
