中国医院用药评价与分析Issue(5)：590-591,592,3.DOI:10.14009/j.issn.1672-2124.2015.05.011
氟哌噻吨美利曲辛治疗脑卒中后抑郁和（或）焦虑症的临床观察
Clinical Efficay of Flupentixol Melitracen Tablets for Post-stroke Depression and
普华1
作者信息
- 1. 河南省第二人民医院药剂科，河南郑州 451191
- 折叠
摘要
Abstract
OBJECTIVE:To evaluate the clinical efficacy of Flupentixol Melitracen tablets for post-stroke depression and( or) anxiety disorder.METHODS: Between Oct.2011 and Oct.2014, a total of 120 patients with post-stroke depression and( or) anxiety disorders were randomized to either treatment group or control group of 60 cases each.The treatment group received add-on Flupentixol Melitracen tablets(2-4 tablets daily) while the control group received amitriptyline (1-2 tablets/time multiply three times daily) for 8 weeks.Hamilton Depression Rating Scale ( HAMD ) , Hamilton Anxiety Scale ( HAMA ) , Clinical Global Impression Scale ( CGI ) and Treatment Emergent Sympton Scale ( TESS) were employed for evaluation of the efficacy and adverse drug reactions of two drugs;General Quality Of Life Inventory ( GQOLI) was used for evaluation of the quality of life of patients.RESULTS:After 8-week treatment, the total score in HAMD and HAMA in the treaetment group were significantly lower than before treatment ( P<0.01 ) and the adverse reactions were less in the treaetment group than in the control group ( P<0.01 ) , CGI score and GQOLI score increased than before treatment.CONCLUSIONS:Flupentixol Melitracen is safe and effective and convinent to use in treatment of post-stroke depression and ( or) anxiety disorder.关键词
氟哌噻吨美利曲辛片/抑郁症/焦虑症Key words
Flupentixol Melitracen tablet/Depression/Anxiety分类
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普华..氟哌噻吨美利曲辛治疗脑卒中后抑郁和（或）焦虑症的临床观察[J].中国医院用药评价与分析,2015,(5):590-591,592,3.
