中国医院用药评价与分析Issue(5)：601-603,3.DOI:10.14009/j.issn.1672-2124.2015.05.015
复方苦参注射液联合奈达铂胸腔内注入治疗肺癌恶性胸腔积液的临床观察
Effiacy and Safety of Compound Kushen Injection plus Nedaplatin for Malignant Pleural Effusion in Patients with Lung Cancer
张遂甫 1陈晓平 1陈永生 1包磊 1张腾1
作者信息
- 1. 舞阳县人民医院呼吸科，河南漯河 462400
- 折叠
摘要
Abstract
OBJECTIVE:To evaluate the efficacy and safety of Compound Kushen injection plus nedplatin for malignant pleural effusion in patients with lung cancer.METHODS: 112 patients with lung cancer and malignant pleural effusion were randomly assigned to either treatment group or control group of 56 cases each.The patients in both groups were inserted with central venous catheter in pleural cavity for drainage of pleural effusion.After clearance of pleural effusion or when the daily volume of drainage was less than 100 ml, the patients in the treatment group were intrapleurally injected with Kusen injection (30 ml) plus nedaplatin (60 mg) and dexamethasone (10 mg) weekly for four consecutive weeks, while the patients in the control group were intrapleurally injected with nedaplatin nedaplatin (60 mg) plus dexamethasone (10 mg) weekly for four consecutive weeks.After treatment completion, the curative efficacy and adverse drug reactions in the two groups were evaluated.RESULTS:The total effeetive rate was 80.4%(45/56) in the treatment group vs.58.9%(33/56) in the control group, showing statistically significant difference between the two groups ( P <0.05 ) .76.8% ( 43/56 ) in the treatment group vs.55.4% ( 31/56 ) in the control group showed improvement in quality of life, showing statistically significant difference between the two groups ( P<0.05).The adverse drug reactions including gastrointestinal reactions, chest pain, bone marrow suppression etc were milder in the treatment group than in the control group.CONCLUSIONS:Compound Kushen injection plus nedaplatin was proved to be a safe and feasible therapy with confirmed efficacy and mild adverse reaction in treatment of malignant pleural effusion in patients with lung cancer.关键词
复方苦参注射液/奈达铂/肺癌/恶性胸腔积液Key words
Compound Kushen injection/Nadplatin/Lung cancer/Malignant pleural effusion分类
医药卫生引用本文复制引用
张遂甫,陈晓平,陈永生,包磊,张腾..复方苦参注射液联合奈达铂胸腔内注入治疗肺癌恶性胸腔积液的临床观察[J].中国医院用药评价与分析,2015,(5):601-603,3.
