中国医院用药评价与分析Issue(6)：730-731,732,3.DOI:10.14009/j.issn.1672-2124.2015.06.010
α－硫辛酸联合甲钴胺治疗化疗药引起周围神经病变的疗效观察
Efficacy of α-Lipoic Acid combined with Mecobalamin for Chemotherapy-induced Peripheral Neuropathy
郑志高 1陈毅德 1洪东花 2林雨标 1郑文慧1
作者信息
- 1. 厦门市海沧医院肿瘤科，福建厦门 361021
- 2. 厦门市海沧医院肾内科，福建厦门 361021
- 折叠
摘要
Abstract
OBJECTIVE:To evaluate the clinical efficacy of α-lipoic acid plus mecobalamin for peripheral neuropathy induced by chemotherapy.METHODS:One hundred and tweenty six patients with chemotherapy-induced peripheral neuropathy were randomly divided into two groups ( of 63 cases each) to be treated with eitherα-lipoic acid (600 mg) q.d by intravenous infusion plus mecobalamin (500 μg) q.d by intravenous injection ( treatment groups) or with mecobalamin (500μg) q.d by intravenous infusion ( control group) for 2 weeks, the clinical efficacy between the two groups were compared.RESULTS: The response rate in the treatment group was better than in the control gorup [ 80.95%( 51/63 ) vs.47.62%( 30/63 ) , P <0.05 ] . CONCLUSIONS: α-Lipoic acid combined with mecobalamin are safe and effective in the treatment of peripheral neuropathy induced by chemotherapy.关键词
药物疗法/副作用/周围神经系统疾病/药物疗法/硫辛酸/甲钴胺Key words
Drug therapy/adverse effects/Peripheral nervous system diseases/drug therapy/Thioctic acid/Mecobalamine分类
医药卫生引用本文复制引用
郑志高,陈毅德,洪东花,林雨标,郑文慧..α－硫辛酸联合甲钴胺治疗化疗药引起周围神经病变的疗效观察[J].中国医院用药评价与分析,2015,(6):730-731,732,3.
