中国医院用药评价与分析Issue(6)：813-814,815,3.DOI:10.14009/j.issn.1672-2124.2015.06.040
维格列汀对2型糖尿病患者尿8－羟基脱氧鸟苷水平的影响
Effect of Vildagliptin on Urinary 8-hydroxy-deoxyguanosine in Patients with Type 2 Diabetes Mellitus
郭中秋 1廖庆辉 1赖康保 1史治宙 1陈玉华 1谭娅琴 1王娟1
作者信息
- 1. 深圳市龙岗区人民医院内分泌科，广东 深圳518172
- 折叠
摘要
Abstract
OBJECTIVE:To evaluate the effect of vildagliptin on 8-hydroxy-deoxyguanosine (8-OHdG) in urine of patients with type 2 diabetes mellitus ( type 2 diabetes melitus.T2DM) and investigate its antioxidative stress effect and efficacy in the prevention and treatment of diabetic complications.METHODS:82 T2DM patients with poor blood glucose control were randomized to either combined vildagliptin treatment group ( group A ) or sulfonylurea drug treatment group ( group B ) for treatment of 12 weeks.Fasting blood glucose ( FBG ) , glycosylated hemoglobin ( HbA1c) and urinary 8-OHdG levels in the 2 groups were recorded before and after treatment.RESUTLS: After completion of 12-week treatment, among a total of 75 cases including 37 cases in group A and 38 cases in group B, 2 in group A and 2 in group B were lost to follow-up, and 2 in group A and 1 in group B were excluded because of failure to meet the target of blood glucose control.After 12 weeks of treatment, compared with before treatment, FBG, HbA1c and urinary 8-OHdG levels decreased significantly in both groups (P<0.01);the differences between the two groups in FBG, HbA1c levels were of no statistical significance (P>0.05), but the differences in urinary 8-OHdG levels have significant difference ( P<0.05 ) .CONCLUSIONS: The action of vildagliptin to reduce urinary 8-OHdG level and attenuate oxidative stress in patients with T2DM may be one of the mechanisms underlying its efficacy in the prevention and treatment of diabetic nephropathy and other chronic complications.关键词
2型糖尿病/8-羟基脱氧鸟苷/维格列汀Key words
Type 2 diabetes/8-hydroxydeoxyguanosine/Vildagliptin分类
医药卫生引用本文复制引用
郭中秋,廖庆辉,赖康保,史治宙,陈玉华,谭娅琴,王娟..维格列汀对2型糖尿病患者尿8－羟基脱氧鸟苷水平的影响[J].中国医院用药评价与分析,2015,(6):813-814,815,3.
