中国真菌学杂志Issue(3)：134-138,5.
靶向金纳米棒对隐球菌活性影响的体外实验研究
Effect of targeted gold nanoparticles on viability of Cryptococcus neoformans in vitro research
摘要
Abstract
Objective To design targeted gold nanoparticles (GNP) conjugated with anti⁃Cryptococcus neoformans antibody,to explore targeted gold nanoparticles⁃mediated photothermal therapy of Cryptococcus neoformans in vitro. Methods Gold nanoparticles were synthesized according to seed⁃mediated template⁃assisted protocol,conjugated with anti⁃Cryptococcus neoformans antibody( Ab) . Cryptococcus neoformans were incubated with targeted gold nanoparticles,then exposed to near⁃infrared (NIR) light.Cell viability was evaluated.Results Targeted gold nanoparticles were synthesized successfully and can be used to selectively target Cryptococcus neo⁃formans cells and following NIR laser exposure,can be used to significantly reduce cell viability.Conclusions These results demong⁃strated that Ab⁃mediated immunity gold nanoparticles can enhance NIR photothermal treatments effect on Cryptococcus neoformans.关键词
隐球菌/金纳米棒/光热治疗Key words
gold nanoparticles/Cryptococcus neoformans/photothermal treatments分类
医药卫生引用本文复制引用
肖琴,陈敏,徐楠..靶向金纳米棒对隐球菌活性影响的体外实验研究[J].中国真菌学杂志,2015,(3):134-138,5.基金项目
国家自然科学基金（81201234），上海市卫生局科研课题 （）
