中国真菌学杂志Issue(3)：175-180,181,7.
基于新靶点的抗真菌药物研究进展
The research progress on new targets of antifungal candidates
摘要
Abstract
Invasive fungal infections are devastating with increasing morbidity and substantial mortality.Unfortunately,classic anti⁃fungal agents are limited by their antifungal spectrums,adverse effects,drug⁃drug interactions,variable pharmacokinetics,and limit types of formulation.Therefore,novel antifungal agents are urgently needed for the treatment of serious invasive fungal infections.It is possible that antifungal agents with novel targets will provide favorable options to treat fungal infections.It has made great development in antifungal agents research recent years,and the exciting advances are represented by four clusters of antifungal candidates.The first is the novel approach of candidates that destroy fungal cell walls,like E1210 and D11⁃2040.The second important finding is the can⁃didates that block protein kinases signaling pathways or protein phosphatase signaling pathways,such as KP⁃372⁃1,17⁃AAG,and My⁃cograb;The third area pertains to candidates that target fungal virulence factors,like C7,213Bi⁃18B7,188Re⁃18B7 and so on.The fourth is the candidates that activate the host immune system,including PEV7 andβ⁃(Man)3⁃Fba⁃TT.Over all,these four areas demonstrate the exciting research progress on new targets of antifungal agents.关键词
抗真菌/靶点/化合物/抗体/疫苗Key words
antifungal/target/compound/antibody/vaccine分类
医药卫生引用本文复制引用
黄鑫,刘颖,陈思敏,安毛毛,姜远英..基于新靶点的抗真菌药物研究进展[J].中国真菌学杂志,2015,(3):175-180,181,7.基金项目
国家自然科学基金（81330083），科技部新药创制重大专项 （）
