中国中西医结合外科杂志Issue(5)：477-479,3.DOI:10.3969/j.issn.1007-6948.2014.05.004
重症腹腔结核患者外周血和腹水中Th17细胞及其相关因子的水平和意义
Detection and Significance of Th17 Lymphocytes and Related Factors in Peripheral Blood and Ascites of Patients with Severe Abdominal Tuberculosis
白婕 1张建 1李莉 1李强 1张学丽2
作者信息
- 1. 天津市海河医院 普外科
- 2. 天津市海河医院 结核科 天津 300350
- 折叠
摘要
Abstract
Objective To detect Th17 lymphocytes and its related factors in peripheral blood and ascites of patients with severe abdominal tuberculosis and to discuss the changes of Th17 lymphocytes in its process. Methods The expression ratio of Th17 in peripheral blood using flow cytometry in patients with abdominal tu-berculosis in critical period was determined in convalescence and healthy controls. IL-6, IL-17, IL-23 levels by ELISA in serum of all three groups and in ascites of critical period and convalescence tuberculosis patients were detected. Differences between each set of these indicators and the correlation between the indicators were anal-ysed. Results Both the ratio of Th17 cells sharing CD4+ T cells and the levels IL-6, IL-17 and IL-23 in pe-ripheral blood of critical period patients were significantly higher than those in the convalescent patients and healthy controls, the difference between convalescent patients and healthy controls was not statistically signifi-cient. The levels of IL-6, IL-17 and IL-23 in ascites in critical period were higher than those in convalescence patients with statistically significant difference. Th17 cell ratio in patients with severe abdominal tuberculosis was positively correlated with the levels of IL-6, IL-17 and IL-23 in peripheral blood. Conclusion Th17 cells and related factors plays a certain regulative function in the development of abdominal tuberculosis in patients with severe disease. Exploration of differentiation and regulation mechanism of the cells helps to un-derstand the role in disease progression and to discover the biological therapeutic targets.关键词
腹腔结核/Th17细胞/细胞因子Key words
Abdominal tuberculosis/Th17 cells/cytokines分类
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白婕,张建,李莉,李强,张学丽..重症腹腔结核患者外周血和腹水中Th17细胞及其相关因子的水平和意义[J].中国中西医结合外科杂志,2014,(5):477-479,3.
