中国中西医结合外科杂志Issue(2)：140-143,4.DOI:10.3969/j.issn.1007-6948.2015.02.011
超前应用舒芬太尼对瑞芬太尼术后痛觉过敏的影响
Inhibitive Effect of Sufentanil Advanced Application in Preventing Postoperative Hyperalgesia of Remi-fentanil in Orthopaedic Surgery
李美 1于泳浩1
作者信息
- 1. 天津医科大学总医院麻醉科 天津 300070
- 折叠
摘要
Abstract
Objective To compare the effects of before skin incision and 30 min before the end of opera⁃tion intravenous injection of sulfentanil in preventing postoperative hyperalgesia after remifentanil based total in⁃travenous anesthesia(TIVA). Methods Double-blind comparison principle was taken. Sixty patients undergo⁃ing lower limb fracture operations with remifentanil based TIVA were randomly assigned to 3 groups. Group A:Patients received sulfentanil 0.15 μg/kg before skin incision. Group B: Patients received sulfentanil 0.15 μg/kg at 30 min before the end of operation. Group C(control):Patients did not receive other anesthesia except remifent⁃anil. The blood pressure, heart rate, oxygen saturation and extubation time were recorded at tube drawing. The pain intensity was evaluated by vision assessment score (VAS) at the point of 10,30 min, and 2 h after surgery. The scores of patient agitation were recorded. Results Compared with groups A and B, VAS scores in group C were higher at the point of 10,30 min, and 2 h after surgery. VAS scores in group B was a little less than those in group A at the point of 2 h after surgery (P<0.05). Compared with group A and B, the scores of pa⁃tient agitation in group C were higher at the point of 30min after surgery. The number of patient agitation in group B was a little less than that in group A at the point of 30min after surgery (P<0.05).There were no statistically significant differences within the blood pressure, the heart rate, the oxygen saturation and the extubation time. Conclusion Based on the principle of Preemptive analgesia, before skin incision sulfentanil can prevent postoperative hyperalgesia efficiently, the score of patient agitation and VAS score before skin incision were a little higher than 30 min before the end of operation.关键词
瑞芬太尼/舒芬太尼/痛觉过敏/超前镇痛Key words
Remifentanil/sulfentanil/hyperalgesia/preemptive analgesia分类
医药卫生引用本文复制引用
李美,于泳浩..超前应用舒芬太尼对瑞芬太尼术后痛觉过敏的影响[J].中国中西医结合外科杂志,2015,(2):140-143,4.
