摘要
Abstract
Objective To evaluate the efficacy of dezocine combined with sufentanil for patient-controlled intravenous analgesia (PCIA), so as to provide evidence for rational drug use in clinic. Methods The random⁃ized controlled trials of dezocine combined with sufentanil for PCIA were gathered from PubMed, Embase, and Cochrane database of Systematic Reviews, CNKI and VIP. The data analyses were performed with The Cochrane Collaborations software RevMan 5.0. Results 16 RCTs were included with a total of 1277 cases. The meta-analysis results showed as follows: as for visual analog scale (VAS) score, compared with the sufentanil group, the postoperative VAS at 2-hour was decreased in the combined drug group[WMD=-0.16,95%CI (-0.27,-0.06)]. There was no significance in Ramsay score between combined group and sufentnil group. As for bruggrmann comfort scale (BCS) score, compared with the sufentanil group, the BCS at 2-hour and 48-hour was increased in the combined drug group [WMD=-0.15,95%CI (-0.26,-0.05);WMD=0.24 ,95%CI(0.10,0.37)]. The incidence of adverse reactions in the combination group, compared with the single drug group, such as nausea, vomiting, dizzi⁃ness, was significantly reduced. As for patients’satisfactory degree compared with the sufentanil group, the com⁃bined drug group showed better outcomes [OR=2.56,95%CI(1.36,4.80)]. Conclusion Dezocine combined with sufentanil for PCIA can effectively alleviate postoperative pain compared with single drug group, and reduce the incidence of adverse reactions.关键词
舒芬太尼/地佐辛/病人自控镇痛/Meta分析Key words
Sufentanil/dezocine/patient-controlled intravenous analgesia/meta-analysis分类
医药卫生
