中国中西医结合外科杂志Issue(3)：215-217,218,4.DOI:10.3969/j.issn.1007-6948.2015.03.001
深静脉血栓形成中医证型与黏附因子的相关性研究
Relationship between Deep Vein Thrombosis in Traditional Chinese Medicine Syndromes and Cell Adhe-sion Molecules
摘要
Abstract
Objective To explore the relationship between deep vein thrombosis(DVT) in different syn⁃dromes of Traditional Chinese Medicine(TCM) and cell adhesion molecules. Methods Based on the syn⁃drome differentiation type of TCM, 70 patients with DVT were divided into the syndrome of pathogenic damp⁃ness-heat(A), the syndrome of blood stasis and dampness(B), and 30 healthy people were taken as control. All patients and healthy persons were detected blood serum levels of ICAM-1, P-selectin, E-selectin by immunotur⁃bidimetry. Results The detection of ICAM-1 in A, B and C groups showed respectively:(194.746 ± 18.237) ng/mL, (206.742 ± 23.361) ng/mL, and (160.435 ± 23.410) ng/mL, The DVT levels in patients with ICAM-1 in A and B groups were higher than that in group C(P<0.01), the ICAM-1 level of group B was higher than that in group A (P<0.01). P-selectin in group A, group B and group C expression level showed:(54.093 ± 6.606) ng/mL, (49.889 ± 7.363) ng/mL, and (31.166 ± 6.945) ng/mL, in the order of decreasing, with signifi⁃cant differences(P<0.05, P<0.01). While the E-selectin expression levels in the three groups were:(64.125 ± 8.482) ng/mL, (30.975 ± 8.723) ng/mL, and (27.465 ± 4.934) ng/mL, group A was higher than those in group B and group C (P<0.01, P<0.05), but no significant difference compared with B group and C group (P>0.05). Conclusion There is a certain relationship between cell adhesion molecules and TCM syndrome type of deep venous thrombosis and the level of ICAM-1, P- selectin and E-selectin can help TCM syndrome differentiation .关键词
细胞间黏附因子-1/P-选择素/E-选择素/深静脉血栓形成/中医辨证分型Key words
Intercellular adhesion molecule-1/P-selectin/E-selectin/deep venous thrombosis/syn-drome differentiation type of TCM分类
医药卫生引用本文复制引用
张玥,于婷婷,刘政,王雁南,张玉冬..深静脉血栓形成中医证型与黏附因子的相关性研究[J].中国中西医结合外科杂志,2015,(3):215-217,218,4.基金项目
国家自然科学基金资助项目（30801474）；山东省自然科学基金项目（2008ZRB14035，ZR2010HL033）；山东省中医药科技发展计划项目 （）
