中国中西医结合外科杂志Issue(3)：218-220,3.DOI:10.3969/j.issn.1007-6948.2015.03.002
硫化氢对急性胰腺炎患者血液流变学的影响
Influence of Hydrogen Sulfide on Haemorheology Parameter in Patients with Acute Pancreatitis
摘要
Abstract
Objective To study the influence of hydrogen sulfide on haemorheology parameter in patients with acute pancreatitis. Methods Forty patients suffered from severe acute pancreatitis were selected as group A, 40 patients subjected to mild acute pancreatitis were distributed to group B. Healthy persons were in⁃cluded in control group. Blood was used to detect hydrogen sulfide, haemorheology parameter, protease activated receptor-l (PAR-1)of monocytes, tissue factor (TF)in order to investigate he influence of hydrogen sulfide on pa⁃tients' haemorheology parameter with acute pancreatitis.. Results Erythrocyte aggregation index, ESR, plasma viscosity, high blood viscosity, low blood viscosity in patients with severe acute pancreatitis, was significantly higher than that in patients of group B and C. Also, these parameters in group B were predominantly higher than in group C(P<0.01). H2S, PAR-1,TF in patients of group A were(42.57±7.18)μmol/L,38.53±9.84,(344.24± 28.47)ng/L respectively. In group B, they were(35.27±3.14)μmol/L,23.42±5.16 and(271.67±31.45)ng/L re⁃spectively. In group C, these values were (24.38 ± 2.69)μmol/L,4.53 ± 2.12,(5.63 ± 3.24) ng/L. The three values in group A were obviously higher than those in group B and C. H2S positively correlated with erythrocyte aggre⁃gation index, ESR, plasma viscosity,high blood viscosity, low blood viscosity, PAR-1, TF(r= 0.87,0.74,0.81,0.67, 0.78,0.87,0.86, respectively). Conclusion Endoge⁃nous H2S, as a inflammatory factor, up-regulates PAR-1 and TF which makes haemorheology parame⁃ter abnormal in patients with acute pancreatitis .关键词
急性胰腺炎/硫化氢/血液流变学Key words
Acute pancreatitis/hydrogen sulfide/haemorheology分类
医药卫生引用本文复制引用
黄敏,卢根林,斯伟宏,吴爱兵..硫化氢对急性胰腺炎患者血液流变学的影响[J].中国中西医结合外科杂志,2015,(3):218-220,3.基金项目
国家自然科学基金青年科学基金项目(81201672)；义乌市人才引进项目科研启动基金项目 （81201672）
