中国中西医结合外科杂志Issue(3)：252-255,4.DOI:10.3969/j.issn.1007-6948.2015.03.012
雷公藤多甙干预腔内治疗后血管再狭窄
Lower Extremity Arteriosclerosis Obliterans Occurred Vascular Stent Restenosis after Treatment with Tripterygium Glycosides
摘要
Abstract
Objective:To observe the intervention and clinical effects of patients with lower extremity arterio⁃sclerosis obliterans occurred vascular stent restenosis after treatment with tripterygium glycosides. Methods One hundred and 20 cases of lower extremity artery occlusive disease were randomly divided into three groups after treatment with intracavitary therapy (balloon dilation and stent implantation), 40 cases as control group,40 cases as lower dose treatment group with tripterygium glycosides and 40 cases as higher dose treatment group with tripterygium glycosides, The patients of three groups were given basic therapy, those of treatment groups took tripterygium glycosides orally twice a day,60 days a course, the lower dose group took 0.5 mg·kg-1·d-1,the higher dose group took 1 mg·kg-1·d-1. The blood levels of IL-10, IL-18 and Intima-Media Thickness(IMT)of lower extremity artery were detected pre-treatment and 4 weeks and 12weeks after treatment,all patients were followed-up for 6 months,the rates of stent patency and the side effects were observed. Results Five cases had side effects in treatment groups and the side effects went back to normal after the patients stopped treat⁃ment,the blood levels of IL-10 and IL-18 and Intima-Media Thickness(IMT)of lower extremity artery of the pa⁃tients was significantly higher after a month of opera⁃tion than pre-operation in control group (P<0.01), at the same term,the blood levels of IL-10、IL-18 and IMT of lower extremity artery of the patients in <br> the two treatment groups were significantly lower than those in control group(P<0.01),As comparing the blood levels of IL-10, IL-18 and IMT of lower extremity artery of the patients between the two treatment groups after a month of operation, it was significantly lower in the higher dose treatment group than that in lower does treat⁃ment group but without statistical significance. there was no significant difference between the two treatment groups after 2 months of operation. The rate of stent patency of patients in the treatment group was significantly higher than that in control group. Conclusion Tripterygium glycosides can be used to reduce the rate of vas⁃cular stent restenosis of the patients with lower extremity arteriosclerosis obliterans by immunosuppressive effect and to improve ischemic symptoms of the limb.关键词
支架内再狭窄/免疫排斥反应/雷公藤多甙Key words
Vascular stent restenosis/immunological rejection/tripterygium glycosides分类
医药卫生引用本文复制引用
韩冰,张宏光,李玉媛,周晨光,吉国辉,杨錚,张亮,赵磊..雷公藤多甙干预腔内治疗后血管再狭窄[J].中国中西医结合外科杂志,2015,(3):252-255,4.基金项目
河北省2013年医学研究课题计划项目(20130015) （20130015）
