中国执业药师Issue(9)：3-8,6.DOI:10.3969/j.issn.1672-5433.2014.09.001
8548例血流感染病原菌分布及耐药性分析
Analysis of Pathogen Distribution and Drug Resistance in 8 548 Case of Bloodstream Infection
张凯 1喻华 1黄湘宁 1刘鑫 1黄影1
作者信息
- 1. 四川省医学科学院·四川省人民医院检验科，四川 成都 610072
- 折叠
摘要
Abstract
Objective: To analyze the characteristics of pathogen distribution and drug resistance in bloodstream infection from 2012 to 2013 in Sichuan province so as to provide the basis for clinical rational use of antimicrobial a-gents . Methods: The samples of 8 548 patients who were clinical blood culture positive were collected from 54 hospi-tals in Sichuan province . Tests were conducted for strain identification and MIC and disc diffusion methods (KB method) were adopted for susceptibility test . The results were interpreted according to the Clinical Laboratory Stan-dards Institute (CLSI , 2012 edition ) , and WHONET 5 . 6 software was used for the analysis of drug resistance . Re-sults: Of 8 548 bacterial strains,gram-negative bacteria and gram-positive cocci accounted for 51.5%(4 407/8 548) and 45.9% (3 929/8 548) respectively, fungi and anaerobic bacteria accounted for 2.2% (192/8 548) and 0.2% (20/8 548). The separation rate of Escherichia coli and Pneumonia klebsiella bacteria was 26%(2 223/8 548) and 8.8%(756/8 548) re-spectively . The detection rate of coagulase negative Staphylococcus aureus and Staphylococcus aureus was 32 . 8%( 2 806/8 548 ) and 7 . 3% ( 628/8 548 ) respectively . The sensitivity of Escherichia coli and Klebsiella pneumoniae to imipenem was 99 . 7% and 98 . 7%. The resistance rate of Acinetobacter baumannii to imipenem was 71 . 4%. MRSA de-tection rate was 30 . 2%, while MRCNS detection rate was up to 66 . 9%. No Staphylococcus aureus was found resistant to vancomycin or linezolid . The resistance rate of Coagulase-negative staphylococci and Staphylococcus aureus to te-icoplanin was 3 . 9% and 0 . 9% respectively . The resistance rate of Enterococcus faecium and Enterococcus faecalis to linezolid was 0 . 8% and 0 . 9%, and to vancomycin was 4 . 3% and 0 . 9% respectively . No teicoplanin-resistant strain was found . To most antibiotics , the antibiotic resistance in Enterococcus faecium was significantly higher than in Ente-rococcus faecalis . Conclusion: Blood infection strains are mainly gram-negative bacteria . E . coli is the main bacterial infection strain . The infection of Coagulase negative staphylococcus should not be neglected either .关键词
血培养阳性/病原菌分布/耐药性Key words
Blood Culture Positive/Pathogen Distribution/Drug Resistance引用本文复制引用
张凯,喻华,黄湘宁,刘鑫,黄影..8548例血流感染病原菌分布及耐药性分析[J].中国执业药师,2014,(9):3-8,6.
