中国执业药师Issue(9)：9-11,15,4.DOI:10.3969/j.issn.1672-5433.2014.09.002
糖尿病患者合并血流感染病原菌分布及耐药性分析
Analysis of Pathogen Distribution and Drug Resistance in Diabetes Combined with Bloodstream Infection
胡浩 1杨广涛1
作者信息
- 1. 连云港市第二人民医院内分泌科，江苏连云港222023
- 折叠
摘要
Abstract
Objective: To understand the pathogen distribution and drug resistance in diabetes combined with blood-stream infection. Methods: A retrospective analysis wag made of the blood cultivation data of 100 diabetes with blood-stream infection in our hospital from January of 2008 to June of 2014. Results:Through blood cultivation test,the following pathogens were found from the diabetes complicated with infection: 57 strains of Escheriehia coli. (40 ESBL positive strains),18 strains of Klebsiella pneumoniae (7 ESBL positive sreains),13 strains of Acinetobacter baumannii and 12 strains of Staphylococcus aureus (6 MRSA positive strains). The susceptibility test showed those antibiotics were mainly sensitive to Gram-negative bacilli,such as semisynthetic penicillin with enzyme inhibitor,the third generation of cephalosporin with enzyme inhibitor,over three generations of quinolones,aminoglycosides and carbapenem,and vancomycin,trimetho-prim-sulfamethoxazole and furadantin were responsive to Gram-positive cocci. Conclusion:The pathogens from type 2 dia-betes combined with bloodstream infection were most Gram-negative bacilli,especial Escheriehia coli. The antibacterials sensitive to Gram-negative bacteria include carbapenem,semisynthetic penicillin with enzyme inhibitor,aminoglycosides, the third generation of cephalosporin with enzyme inhibitor and over three generations of cephalosporins. Because of most diabetes combined with kidney diseases,caution is required in the use of aminoglycosides and quinolones. Carbapenem,semisynthetic penicillin with enzyme inhibitors and the third generation of cephalosporins with enzyme inhibitor have a broad and strong antibacterial spectrum and can be used as the first choice for treatment.关键词
糖尿病/血流感染/病原菌/抗菌药/耐药Key words
Diabete/Bloodstream Infection/Pathogens/Antibacterials/Drug Resistance引用本文复制引用
胡浩,杨广涛..糖尿病患者合并血流感染病原菌分布及耐药性分析[J].中国执业药师,2014,(9):9-11,15,4.
