中国执业药师Issue(9)：23-26,4.DOI:10.3969/j.issn.1672-5433.2014.09.006
不同生产厂家的0.9%氯化钠注射液对奥美拉唑钠配伍稳定性的影响
The Impact on Compatible Stability of Omeprazole Sodium by 0 . 9% Sodium Chloride Injection Produced by Different Manufacturers
肖莹 1徐彦贵 1张弋 1李淑娟1
作者信息
- 1. 天津市第一中心医院药学部，天津 300192
- 折叠
摘要
Abstract
Objective: To study the impact on the compatible stability of omeprazole sodium for injection by 0 . 9%sodium chloride injection produced by different manufacturers . Methods: Omeprazole sodium for injection was added into 100 ml of 0 . 9% sodium chloride injection produced by different manufacturers and the mixture was exposed under natural light , hard light and UV respectively . The changes of appearance , pH , content and insoluble particles were observed at 0 , 2 , 4 , 6 , 8 h after the addition . Results: Under three kinds of illumination conditions , the mixture of omeprazole sodium for injection and 0 . 9% sodium chloride injection produced by different manufacturers was all clear and colorless . The insoluble particles met with the requirements set forth in the Chinese Pharmacopoeia . PH showed much impact on the stability , the higher pH the better the stability was . The degree of content changes under three illuminations was UV>hard light>natural light . Conclusion: The compatible stability of omeprazole sodium for injection is related to the pH of infusion .关键词
注射用奥美拉唑钠/0.9%氯化钠注射液/配伍稳定性Key words
Omeprazole Sodium for Injection/0 . 9% Sodium Chloride Injection/Compatible Stability引用本文复制引用
肖莹,徐彦贵,张弋,李淑娟..不同生产厂家的0.9%氯化钠注射液对奥美拉唑钠配伍稳定性的影响[J].中国执业药师,2014,(9):23-26,4.
