中国中医药信息杂志Issue(9)：64-67,4.DOI:10.3969/j.issn.1005-5304.2014.09.019
双黄连注射液类过敏反应研究
Study on Anaphylactoid Reaction Induced by Shuanghuanglian Injection
摘要
Abstract
Objective To observe the anaphylactoid reactions of Shuanghuanglian injection, determine the serum histamine level of sensitized animal, and to investigate its correlation with anaphylactoid reactions.Methods The guinea pigs were randomly selected to observe the anaphylactoid reactions using Shuanghuanglian injections in the different injection speed or different doses, and the serum histamine and the serum IgE of sensitized animals were determined by ELISA. Results The anaphylactoid reactions were induced by Shuanghuanglian injections in the different conditions of injection speed and doses in guinea pigs. There were no obvious difference about the serum IgE level between Shuanghuanglian group and saline group were injected in injection speed and doses. The serum histamine level was significantly increased in Shuanghuanglian group both different conditions of injection speed and doses, and it related to doses and speed. Conclusion Shuanghuanglian injection can cause anaphylactoid reactions in guinea pigs, and the changes of serum histamine level are related to injection speed and doses of Shuanghuanglian injection.关键词
双黄连注射液/类过敏反应/血清免疫球蛋白E/血清组胺Key words
Shuanghuanglian injection/anaphylactoid reaction/serum IgE/serum histamine分类
医药卫生引用本文复制引用
黄崇刚,莫宗成,吴思澜,罗超利,王敏..双黄连注射液类过敏反应研究[J].中国中医药信息杂志,2014,(9):64-67,4.基金项目
重庆市卫生局中医药科技项目(2011-2-118)；重庆市科委项目(cstc2012pt-kyys10001) （2011-2-118）
