中国中医药信息杂志Issue(10)：26-28,3.DOI:10.3969/j.issn.1005-5304.2014.10.009
膝关节骨性关节炎患者中医体质类型与血清转化生长因子-β1表达水平的相关性
Relationship between TCM Constitutional Types and TGF-β1 Levels in Serum of Patients with Knee Osteoarthritis
摘要
Abstract
Objective To discuss the relationship between TCM constitutional types and the levels of transforming growth factor beta 1 (TGF-β1) of patients with knee osteoarthritis (KOA). Methods A total of 161 patients with KOA as a case group filled out questionnaires about 9 TCM constitution types, and 50 cases of unrelated healthy volunteers were selected randomly as control group. The serum samples of two groups were collected. The levels of TGF-β1 were detected and compared by double antibody sandwich ELISA. Results Compared with the control group, the level of TGF-β1 in the case group decreased, with statistical significance (P<0.05). Compared with the control group, the levels of TGF-β1 significantly decreased in the case group of qi deficiency type, with statistical significance (P<0.05). There were no types of special intrinsic and blood stasis. Compared with the control group, the levels of TGF-β1 in the other six types of patients with KOA had no statistical significance (P>0.05). Conclusion The incidence of KOA with qi deficiency type may be related to the decrease of TGF-β1 level. The decreasing level of TGF-β1 may be one of the mechanisms of molecular biology that qi deficiency was linked to KOA.关键词
中医体质类型/膝关节骨性关节炎/转化生长因子-β1/气虚质Key words
TCM constitution type/knee osteoarthritis/TGF-β1/qi deficiency constitution分类
医药卫生引用本文复制引用
周明旺,王晓萍,李盛华,郭铁峰,孙凤歧,穆欢喜..膝关节骨性关节炎患者中医体质类型与血清转化生长因子-β1表达水平的相关性[J].中国中医药信息杂志,2014,(10):26-28,3.基金项目
甘肃省教育厅资助项目(1106B-16) （1106B-16）
