中国中医药信息杂志Issue(11)：56-58,3.DOI:10.3969/j.issn.1005-5304.2014.11.017
电针对抑郁大鼠海马E-选择素和抵抗素蛋白表达的影响
Influence of Electro-acupuncture on E-Selectin and Resistin Protein Expression in Hippocampus of Rats with Chronic Stress Depression
摘要
Abstract
Objective To observe the effects of electro-acupuncture on the E-selectin and resistin protein expression in the hippocampus of rats of chronic stress depression;To explore the role and mechanism of electro-acupuncture in the micro-environment of brain with depression. Methods 40 Fourty rats were randomly divided into four groups:blank group, model group, model+EA group, and model+fluoxetine group by using chronic stress combined with solitary raising methods, 10 rats in each group. Electro-acupuncture intervention was used 1 hour before the modeling. Electro-acupuncture was given at points Baihui (Du 20) and Yintang (Extra) for twenty minutes (2 Hz, 0.6 mA) every day. Fluoxetine was given at the volume of 5 mL/kg, dosage of 10 mg/kg. E-selectin and resistin protein expression in hippocampus were determined by biotin label-based antibody array. Results Compared with the blank group, the protein expression of E-selectin and resistin in the model group increased (fold change=1.23, 1.22). Compared with the model group, E-selectin and resistin expression decreased (fold change=0.65, 0.62;fold change=0.76, 0.65). Conclusion Electro-acupuncture intervention could down-regulate E-selectin and resistin expression in the hippocampus of chronic stress depression model.关键词
电针/抑郁症/慢性应激/海马/血管内皮细胞/E-选择素/抵抗素/大鼠Key words
electro-acupuncture/depression/chronic stress/hippocampus/vascular endothelial cell/E-selectin/resistin/rats分类
医药卫生引用本文复制引用
胡诚,张丹妹,包伍叶,宋映周,史榕荇,图娅,邬继红..电针对抑郁大鼠海马E-选择素和抵抗素蛋白表达的影响[J].中国中医药信息杂志,2014,(11):56-58,3.基金项目
国家自然科学基金面上项目(81173334)；北京中医药大学自主选题项目(0100604217) （81173334）
