中国中医药信息杂志Issue(12)：15-18,4.DOI:10.3969/j.issn.1005-5304.2014.12.005
肾衰Ⅱ号方对慢性肾脏病患者肾功能及炎症因子的影响
Effects of Meliorated Renal Failure Decoction on Renal Function and Inflammatory Cytokines in Patients with Chronic Kidney Disease at 3-4 Stage
摘要
Abstract
Objective To investigate the effects of meliorated renal failure decoction (MRFD) on renal function and inflammatory cytokines in patients with CKD 3-4 stages. Methods Sixty-two patients with CKD 3-4 stages were divided into treatment group and control group through random number table method. Both groups were given conventional treatment of western medicine, and the treatment group was given MRFD additionally. After 6 months of treatment, the changes of TCM symptom scores, Hb, Scr, BUN, 24 h UP, IL-6, IL-8, TNF and eGFR were observed. Meanwhile, the clinical efficacy was evaluated. Results The total clinical effective rate in treatment group was 65.63%(21/32), and 30.00%(9/30) in the control group (P<0.01);the effective rate of TCM syndromes in treatment group was 96.88%(31/32), and 53.33%(16/30) in the control group (P<0.01). The symptoms were improved better in the treatment group than the control group except for the symptoms of dry mouth and throat, and diarrhea. The level of eGFR in treatment group increased obviously (P<0.05), while the levels of Scr, 24 h UP and BUN decreased (P<0.05, P<0.01), with statistical significance between the two groups ( P<0.01). The level of eGFR increased, and the levels of Scr decreased in the control group (P<0.01). The levels of IL-6, IL-8, and TNF in both groups were reduced, while the level of Hb increased in the two groups, without statistical significance (P>0.05). Conclusion MRFD can improve TCM syndrome and renal function, delay the progress of patients with CKD at 3-4 stage by means of reducing the inflammatory cytokines and inhibiting micro-inflammatory state.关键词
肾衰Ⅱ号方/慢性肾脏病/微炎症状态/中西医结合疗法Key words
meliorated renal failure decoction/chronic kidney disease/micro-inflammatory state/combined therapy of Chinese and western medicine分类
医药卫生引用本文复制引用
杨婧,严睿俊,王琛,何立群..肾衰Ⅱ号方对慢性肾脏病患者肾功能及炎症因子的影响[J].中国中医药信息杂志,2014,(12):15-18,4.基金项目
教育部博士学科点专项基金项目(2012310711004)；上海市中医药事业发展三年行动计划(ZYSNXD-CC-MZY044)；上海高校创新团队建设项目(201203) （2012310711004）
