中国中医药信息杂志Issue(4)：77-82,6.DOI:10.3969/j.issn.1005-5304.2015.04.022
大鼠体内川芎多成分序贯代谢研究
Study on Multicomponent Sequential Metabolism in Rats with Chuanxiong Rhizoma
摘要
Abstract
Objective To study the multicomponent in vivo dynamic process in Chuanxiong Rhizoma;To elaborate in vivo metabolic profiling. Methods HPLC was used to establish the fingerprint of aqueous extract of Chuanxiong Rhizoma, and multicomponent changes were detected at the same time. Closed-loop intestine method was used to study the multicomponent changes of oral administration of Chuanxiong Rhizoma after stomach-intestine-liver process. Results Totally 17 components were detected in the fingerprint of aqueous extract of Chuanxiong Rhizoma and they were basically stable in the digestive juice. For in vivo metabolism, 4 components were metabolized by intestinal flora;3 components were metabolized by liver;2 new components were the metabolites of intestinal flora;1 component was the metabolite of liver. Conclusion Multicomponent sequential metabolism and closed-loop intestine method were used to clarify that multicomponent metabolic profiling was feasible, and it could provide experimental basis for the metabolism of traditional Chinese medicine.关键词
川芎/多成分/序贯代谢/封闭肠环/大鼠Key words
Chuanxiong Rhizoma/multicomponent/sequential metabolism/closed-loop intestine method/rats分类
医药卫生引用本文复制引用
吕贝然,杨文宁,唐明敏,隗丽,马晓云,罗志强,刘洋..大鼠体内川芎多成分序贯代谢研究[J].中国中医药信息杂志,2015,(4):77-82,6.基金项目
国家自然科学基金(81274042) （81274042）
