中国中医药信息杂志Issue(5)：60-64,5.DOI:10.3969/j.issn.1005-5304.2015.05.017
天芪益智颗粒对阿尔茨海默病大鼠脑组织线粒体及能量代谢的影响
Effects of Tianqi Yizhi Granules on Mitochondria of Brain Tissues and Energy Metabolism ;in Alzheimer Rats
摘要
Abstract
Objective To investigate the action mechanism of Tianqi Yizhi Granules for Alzheimer disease. Methods Ninety SD rats were divided into sham-operation group, model group, positive medicine group, high, medium and low dosage of Tianqi Yizhi Granules groups. SD rats were injected with aggregated amyloid β1-42 protein (Aβ1-42) into their left ventricle to establish AD models. Treatment groups received gavage with Huperzine A or Tianqi Yizhi Granules. The sham-operation group and model group received gavage with the same volume of normal saline. The mitochondrial membrane potential, activity of complex Ⅰ, Ⅱ, Ⅲ and Ⅳ of mitochondrial respiratory chain, enzymatic activity of Na+-K+ATP, energy charge, and space leaning ability were detected. Results Compared with model group, Tianqi Yizhi Granules could significantly improve mitochondrial membrane potential, activity of complex Ⅰ, Ⅲ and Ⅳ of mitochondrial respiratory chain, enzymatic activity of Na+-K+ATP, space leaning ability, and energy metabolism of brain in AD rats. Conclusion Tianqi Yizhi Granules showed mitochondrial protective capacity, and could improve energy metabolism of brain in AD rats, and then improve AD rats’ space learning ability.关键词
天芪益智颗粒/阿尔茨海默病/线粒体/能量代谢/学习记忆/大鼠Key words
Tianqi Yizhi Granules/Alzheimer disease/mitochondria/energy metabolism/learning memory/rats分类
医药卫生引用本文复制引用
武义明,赵军,马涛,卫东锋..天芪益智颗粒对阿尔茨海默病大鼠脑组织线粒体及能量代谢的影响[J].中国中医药信息杂志,2015,(5):60-64,5.基金项目
国家科技重大专项-重大新药创制(2013ZX09103002-002)；国家自然科学基金重点项目(81430100) （2013ZX09103002-002）
