中国中医药信息杂志Issue(6)：87-90,4.DOI:10.3969/j.issn.1005-5304.2015.06.025
金茵利胆口服液质量标准研究
Study on Quality Standard of Jinyin Lidan Oral Liquid
摘要
Abstract
Objective To establish the quality standard for Jinyin Lidan Oral Liquid. Methods Artemisiae Scopariae Herba, Taraxaci Herba, Aurantii Fructus and Schisandrae Chinensis Fructus in Jinyin Lidan Oral Liquid were identified by TLC. The contents of naringin and neohesperidin were determined by HPLC. The HPLC separation was performed on Phenomenex C18 column (4.6 mm × 250 mm, 5 μm) with the mobile phase of methanol-0.1% phsophonic acid solution and gradient elution. The UV detection wavelength was 254 nm;flow rate was 1.0 mL/min;column temperature was 25 ℃. Results The results of TLC showed that relevant spots were clear, with strong specificity, without interference of negative sample. The calibration curves for naringin and neohesperidin were in good linearity in the range of 0.56-5.60μg (r=0.999 9) and 0.38-3.80μg (r=0.999 8), respectively. The average recoveries were 99.86%and 98.95%with RSD of 2.04%and 2.45%, respectively. Conclusion The qualitative and quantitative determination method is simple, accurate and reliable, with good stability and reproducibility, and can be used for the quality control of Jinyin Lidan Oral Liquid.关键词
金茵利胆口服液/质量标准/薄层色谱法/高效液相色谱法Key words
Jinyin Lidan Oral Liquid/quality standard/TLC/HPLC分类
医药卫生引用本文复制引用
李彩东,王信,潘新波,张伟..金茵利胆口服液质量标准研究[J].中国中医药信息杂志,2015,(6):87-90,4.基金项目
甘肃省中医药科学技术研究课题(GZK-2012-49) （GZK-2012-49）
