中国中医药信息杂志Issue(7)：78-81,82,5.DOI:10.3969/j.issn.1005-5304.2015.07.022
银杏叶片剂大鼠体内多成分序贯代谢研究
Sequential Metabolism Study on Ginkgo Folium Tablet in Digestive System
摘要
Abstract
Objective To investigate dynamic metabolism in vivo of Ginkgo Folium Tablet under the guidance of sequential metabolism thoughts. Methods In situ closed-loop in rats was carried out to study sequential metabolism of Ginkgo Folium Tablet through oral digestive system, namely to investigate and compare the intestinal flora metabolism, the gut wall metabolism and hepatic metabolism, combined with chromatographic fingerprint of blood samples. Results The analysis showed that 12 peaks in Ginkgo Folium Tablet were metabolized by intestinal flora, and 7 peaks generated through the gut wall. Most components of Ginkgo Folium Tablet were metabolized in liver, and 3 original medicine components were directly into the blood. Conclusion This study conducts a qualitative description of metabolism of Ginkgo Folium Tablet in different parts of the oral route, and provides references for the quality control, mechanism explanation and secondary development for Ginkgo Folium Tablet.关键词
银杏叶提取物片剂/序贯代谢/肝代谢/肠道菌群代谢/肠壁代谢/指纹图谱/封闭肠环法Key words
Ginkgo Folium Tablet/sequential metabolism/hepatic metabolism/intestinal flora metabolism/gut wall metabolism/fingerprint/in situ closed-loop分类
医药卫生引用本文复制引用
张喆,唐明敏,范瑞艳,蔡大任,杨文宁,刘洋..银杏叶片剂大鼠体内多成分序贯代谢研究[J].中国中医药信息杂志,2015,(7):78-81,82,5.基金项目
北京中医药大学大学生科研课题质量工程项目(201310026071) （201310026071）
