中国卒中杂志Issue(6)：493-498,6.DOI:10.3969/j.issn.1673-5765.2014.06.007
缺血性卒中患者急性期认知障碍研究
A Study of the Clinical Features of Cognitive Impairment among Patients with Acute Ischemic Stroke
摘要
Abstract
Objective To explore the features of cognitive impairment among patients with acute ischemic stroke. Methods In this prospective study, data were collected consecutively from 220 in-patients at the Neurology Department of Guangzhou First People's Hospital from March 2011 to June 2012. These patients were assessed with both Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) at the day of enrollment. Simultaneously, a control group of 146 healthy individuals from matched background was also set up. Control subjects were enrolled from community centers, physical examination center in our hospital and some of them were relatives of the patients as well. The patients were classiifed into subgroups based on the total scores of MoCA and MMSE, respectively. There are four subgroup: Group A (MMSE<26, MoCA 23) with 93 patients, Group B (the scores of MMSE are between 26~27, MoCA 23) with 36 patients, Group C (MMSE 28, MOCA 23) with 24 patients, Group D (those with normal scores in both MMSE and MOCA) with 67 patients. Results Patients scored less than the controls overall on both the MMSE (25.07±3.99 vs 27.73±1.89) and MoCA (17.70±5.77 vs 23.96±3.44), (P<0.05). There is no statistic difference in the naming subtests of MoCA in the two groups (patient group 3[2, 3], control group 3[2, 3], P=0.159). A comparison of the subtest scores of MoCA suggests that the subgroup A (visuospatial/executive function [1{0, 2}], naming [2{1, 3}], recall [1{0, 2}], attention [3{2, 5}], language [0{0, 0}], abstraction [0{0, 1}], orientation [4{3, 5}]) and subgroup B (visuospatial/executive function [1{1, 2}], naming [2{1, 3}], recall [2{0, 3}], attention [5{4, 6}], language [0{0, 0}], abstraction [1{1, 2}], orientation [6{5, 6}]) have worse performances than the control group (visuospatial/executive function [4{3, 5}], naming [3{2, 3}], recall [3{2, 4}], attention [6{5, 6}], language [2{1, 2}], abstraction [2{1, 2}], orientation [6{6, 6}]) (P<0.05), while subgroup C show decreased score in visuospatial/executive function (2[1, 3.75]), language (0[0, 0]) and recall (2[1, 3]) (P<0.05). Conclusion Patients with acute ischemic stroke suffered from cognitive impairment in all subdomains of MoCA except naming. Visuospatial/executive function, language and recall impairment are the main clinical features in patients with mild cognitive impairment who cannot be recognized by MMSE.关键词
卒中/血管性认知障碍/临床特征Key words
Stroke/Vascular cognitive impairment/Clinical features引用本文复制引用
陈浩博,潘小平,胡蓉,胡键浠,吴玉,莫小恩..缺血性卒中患者急性期认知障碍研究[J].中国卒中杂志,2014,(6):493-498,6.基金项目
广州市科技计划项目（2012J5100039）广州市科技计划项目 （）
