中国卒中杂志Issue(12)：1007-1013,7.DOI:10.3969/j.issn.1673-5765.2014.12.005
老年缺血性卒中后患者奥氮平直肠给药的临床疗效观察
Study on the Treatment Effectiveness of Per Rectum Olanzapine for Patients with Delirium Post-Stroke
傅小玲 1石玉芝 2高畅 1楚勤英 1李建华 1舒刚明1
作者信息
- 1. 100043 北京解放军总医院第一附属医院干二科
- 2. 首都医科大学附属北京天坛医院神经内科
- 折叠
摘要
Abstract
Objective To investigate the effectivity and safety about olanzapine administered rectally for ischemic stroke old patients. <br> Methods Sixty patients (aged≥65 years) admitted to the Department of Cardre Ward-2 of the First Afifliated Hospital of the General Hospital of People's Liberation Army (PLA) from March 2013 with delirium after a recent stroke was accepted. All these 60 patients were randomly divided into two groups to accept with olanzapine orally or rectally, respectively. All the patients fuliflled the National Institutes of Health Stroke Scale (NIHSS) and the Confusion Assessment Method (CAM) scale before and one week after they used the drug of olanzapine. Compare the baseline data, severity of the stroke and the delirium. One week after the patients used the drug, compare the mean dose of olanzapine, the treatment effect and the side effect of the two groups. We followed up all the 60 patients with modiifed Rankin Scale (mRS) after 3 months to evaluate the prognosis of the two methods of administration. Results ①There is no signiifcant difference between the oral group and the rectal group on the age, gender and the score of NIHSS and CAM: Media of NIHSS (8.5 vs 10;P=0.79)、CAM ([25.8±3.1] vs [26.1±5.3];P=0.79). Also the comorbidity of hypertension (6.7%vs 2.0%;P=0.18), diabetes (10.0%vs 23.3%;P=0.17) and coronary heart disease (CHD) (50.0%vs 60.0%;P=0.43) have no signiifcant differences between the two groups.②Both two groups' olanzapine orally and rectally are both well tolerated among these patients, and there is no signiifcant side effect on those 60 patients in the ifrst week ([5.33±2.12] vs [4.25±2.06];P=0.03).③The follow-up data after 3 months showed that there was no signiifcant difference between the two groups in the score of mRS (P=0.15). <br> Conclusion Olanzapine administered rectally may be an effective and safe method for delirium patients, especially for those patients who are dififculty in taking oral medicine. And the dose of rectal use should be less than that of oral use.关键词
谵妄/卒中/奥氮平/直肠给药Key words
Delirium/Stroke/Olanzapine/Rectal administration引用本文复制引用
傅小玲,石玉芝,高畅,楚勤英,李建华,舒刚明..老年缺血性卒中后患者奥氮平直肠给药的临床疗效观察[J].中国卒中杂志,2014,(12):1007-1013,7.
