中国卒中杂志Issue(1)：50-55,6.DOI:10.3969/j.issn.1673-5765.2015.01.009
缺血性卒中患者平均血小板体积水平与氯吡格雷抵抗的相关性分析
Relationship between the Level of Mean Platelet Volume and Clopidogrel Resistance in Patients with Ischemic Stroke
摘要
Abstract
Objective To observe the relationship between the level of mean platelet volume and clopidogrel resistance in patients with ischemic stroke. Methods The study continuously chose 150 patients with ischemic stroke during March 2013 to January 2014 in Department of Neurology of the Third Afifliated Hospital of Guangzhou Medical University, all patients taking clopidogrel 75 mg/d, and then used turbidimetry to measure the platelet aggregation rate prior to the drug and 10~14 d after having taken clopidogrel. The patients were divided into clopidogrel resistance (CR) group and clopidogel sensitivity (CS) group according to the change of platelet aggregation rate, compared to the general information, risk factors, and the level of mean platelet volume (MPV). Multivariate Logistic regression analysis was used to identify the relationship with the level of MPV and CR. Results Total 150 patients with ischemic stroke were included, CR occurred in 44 of them (29.33%), CS group were 106 cases. In single factor analysis, the MPV level of CR group ([9.55± 0.40] flvs [9.28±0.35]fl,P=0.000) were significantly higher than the CS group. The Logistic regression analysis showed that MPV levels (odds ratio [OR]10.555, 95% confidence interval [CI]2.524~44.134,P=0.001), total cholesterol (OR1.561, 95%CI1.051~2.318,P=0.027), the previous transient ischemic attack (TIA) (OR6.537, 95%CI2.475~17.262,P=0.000) and diabetes(OR7.632, 95%CI2.620~22.228,P=0.000) were correlated with CR. Conclusion The level of MPV is independent risk factors of CR, and it might be used to predict and screen CR in the early time.关键词
缺血性卒中/血小板平均体积/氯吡格雷抵抗/预测价值Key words
Ischemic stroke/Mean platelet volume/Clopidogrel resistance/Predictive value引用本文复制引用
罗建华,周伯荣,钟广宏,石红婷,刘远波,郑翾..缺血性卒中患者平均血小板体积水平与氯吡格雷抵抗的相关性分析[J].中国卒中杂志,2015,(1):50-55,6.基金项目
广东省科技计划资助项目（2011B060300027）广东省科技计划项目 （）
