摘要
Abstract
Objective To evaluate the association between serum 25-hydroxyvitamin D (25 [OH] D) levels and the clinical severity in cerebral infarction patients, and to explore the inlfuence in prognosis of those patients who received 25 (OH) D treatment.
<br> Methods Serum concentrations of 25 (OH) D were measured among 217 patients who developed acute cerebral infarction and 163 health control subjects who were free of stroke. These patients were divided into different groups based on the serum 25 (OH) D concentrations for analyzing the proportion of each group in patients with cerebral infarction and compared with healthy control group. The difference about clinical data and their correlation were evaluated among the cerebral infarction patients with different 25 (OH) D levels. All of the patients with the serum 25 (OH) D<20 ng/ml were divided into two subgroups according to whether received vitamin D therapy and compared in 1 year follow-up for indicators such as serum 25 (OH) D levels, recurrence rates of the endpoint events and average modiifed Rankin Scale scores.
<br> Results The serum 25 (OH) D concentrations were signiifcantly decreased in the cerebral infarction patients compared with the healthy control group, the mean value was (13.67±1.16) ng/ml and (20.11±2.05) ng/ml, respectively (P=0.001). In the cerebral infarction group, the prevalence of 25 (OH) D deficiency and sufficiency, showed obvious differences compared with the healthy control group. Compared to the serum 25 (OH) D≥20 ng/ml, the serum 25 (OH) D<20 ng/ml was more often in the cerebral infarction patients with hypertension, diabetes and coronary heart disease (P=0.010, P=0.011, P=0.037). There was a negative correlation between serum 25 (OH) D level and admission National Institutes of Health Stroke Scale (NIHSS) score in patients (r=-0.720, P=0.001). Among all of the cerebral infarction patients with serum 25 (OH) D levels<20 ng/ml, the subgroup which received vitamin D treatment had a recurrence rate of transient ischemic attack (TIA) or cerebral infarction and an average modiifed Rankin Scale score within one year, both were lower than that not received vitamin D treatment, but showing no statistically signiifcant differences (P=0.080, P=0.079).
<br> Conclusion The lower serum 25 (OH) D levels in the patients with cerebral infarction were associated with the severity, but the evidence was still lacking that vitamin D treatment would reduce the occurrence of risk of ischemic stroke and improve patient prognosis.关键词
25-羟基维生素D/脑梗死/风险Key words
25-hydroxyvitamin D/Cerebral infarction/Risk
