中国卒中杂志Issue(5)：407-412,6.DOI:10.3969/j.issn.1673-5765.2015.05.006
原发性干燥综合征继发中枢神经系统血管炎临床及影像分析
Clinical and Imaging Characteristics of Secondary Central Nervous System Vasculitis Caused by Primary Sjögren's Syndrome
摘要
Abstract
Objective To investigate the clinical and imaging manifestations of secondary central nervous system vasculitis caused by primary Sjögren's syndrome (PSS). Methods Thirty-five inpatients diagnosed as central nervous system involvement secondary vasculitis by Sjögren's syndrome were retrospectively analyzed in Beijing Tiantan Hospital. Results Thirty females and five males were enrolled in this study. The range age was from 18 to 76 (52±14) years old. Twenty-four patients were involved the central nervous system as initial presentations of PSS. The clinical manifestations of acute cerebral vessel disease were 8 patients (22.86%), including 2 subarachnoid hemorrhage (5.71%), 2 transient ischemic attack (5.71%), 2 arteriovenous fistula (5.71%), 1 cerebral hemorrhage (2.86%), 1 venous sinus thrombosis (2.86%). Other clinical manifestations were including 10 cerebral white matter damage, 6 neuromyelitis optica, 5 spinal cord inlfammations, 3 Parkinson syndrome, 2 trigeminal neuralgia, 1 encephalomyelitis. The imaging ifndings were respectively involved in 3 cases of aneurysm (2 cases of subarachnoid hemorrhage) (8.57%), 2 cases of temporal parietal occipital arteriovenous ifstula (5.71%), 2 case of cerebral arterial stenosis (5.71%) and 1 case of superior sagittal sinus thrombosis (2.86%), 20 cases of paraventricular white matter, 16 cases of subcortical white matter, 8 cases of brainstem, 11 cases of spinal cord, 2 cases of slightly larger ventricle. The single lesion stages (no less than 3) of spinal cord/brainstem were 10 patients.Conclusion The onset of central nervous system involvement in PSS could be form of acute cerebrovascular disease, but the cerebral white matter lesions and spinal cord inflammation are most common. The speciifc imaging characteristic is single lesion involving muti-stages.关键词
原发性干燥综合征/继发性中枢神经系统血管炎/影像学Key words
Primary Sjögren's syndrome/Second central nervous system vasculitis/Imaging引用本文复制引用
李伟,李少武,张在强..原发性干燥综合征继发中枢神经系统血管炎临床及影像分析[J].中国卒中杂志,2015,(5):407-412,6.基金项目
首都医科大学基础-临床科研合作基金（14JL54）北京市教育委员会科技计划重点项目 （）
