中国卒中杂志Issue(7)：612-615,4.DOI:10.3969/j.issn.1673-5765.2015.07.013
缺氧诱导因子-1α在脑缺血后对内源性神经干细胞作用的研究进展
HIF-1α Playing a Role of Endogenous Neural Stem Cells after Cerebral Ischemia and Its Research Progress
李栋 1段淑荣1
作者信息
- 1. 150001 哈尔滨哈尔滨医科大学附属第一医院神经内科
- 折叠
摘要
Abstract
Influence factors of promoting the regeneration of endogenous neural stem cells (NSCs) after cerebral infarction are becoming a hot spot of concern for neurological scholars. In recent years, some experiments have been proven that some related factors involved in the brain tissue damage repair process and got highly expressed in the condition of ischemia and hypoxia after cerebral infarction, such as hypoxia-inducible factor-1α (HIF-1α). Experts evaluated the relationships between endogenous NSCs and HIF-1α expression in a photothromobotic rat stroke model using immunohistochemistry and Western blot analysis. The results showed that early expressions of HIF-1α after ischemia made up the microenvironment to increase the nerve regeneration for endogenous NSCs. A large number of studies have shown that high expressions of HIF-1α protect nerve cells from damage after cerebral ischemia in ischemic and anoxic environment and provide the favorable conditions for brain repair.关键词
神经干细胞/神经前体细胞/缺氧诱导因子-1α/血管内皮生长因子/促红细胞生成素/一氧化氮合酶/内环境Key words
Neural stem cell/Neural precursor cell/Hypoxia-inducible factor 1α/Vascular endothelial growth factor/Erythropoietin/Nitric oxide synthase/Microenvironment引用本文复制引用
李栋,段淑荣..缺氧诱导因子-1α在脑缺血后对内源性神经干细胞作用的研究进展[J].中国卒中杂志,2015,(7):612-615,4.
