中华耳科学杂志Issue(1)：37-42,6.DOI:10.3969/j.issn.1672-2922.2015.01.007
氨基糖苷类抗生素对耳蜗螺旋神经节的损害作用
Damaging Effects of Aminoglycoside Antibiotics on Cochlear Spiral Ganglion Neurons
摘要
Abstract
Aminoglycoside antibiotics (AmAn) are widely used for gram negative bacterial infections while they are al⁃so notorious for their ototoxicity and nephrotoxicity. Conventional view is that the ototoxic effects of AmAn can only damage sensory hair cells in the inner ear, and can cause delayed spiral ganglion neurons (SGNs) degeneration as a result of the loss of sensory hair cells. But with deepening of research, people have come to realize that supporting cell damage is also one of the important reasons for the delayed SGNs death. Meanwhile, it has been found that different AmAns may exert their ototoxic ef⁃fects through different approaches to different target cells via different pathways. Streptomycin sulfate, which represents a mi⁃nor category of AmAn, passes easily through the blood-labyrinth barrier and can directly damage peripheral neurons in the in⁃ner ear. AmAns that are believed to have little influence upon SGNs can directly hurt juvenile SGNs harvested from newborn rats at postnatal day 3. Based on the target of drug-specific damage, we propose a new classification criterion that categorizes AmAn according to their different mechanisms of ototoxicity. We hope this review can provide new insights and information for further understanding ototoxic mechanisms by AmAn as well as interrelations among different tissues within the cochlea.关键词
氨基糖苷类抗生素/耳毒性/螺旋神经节神经元/硫酸链霉素/卡那霉素Key words
Aminoglycoside antibiotics/Ototoxicity/Spiral Ganglion Neurons/Streptomycin Sulfate/Kanamycin分类
医药卫生引用本文复制引用
高可雷,丁大连,李鹏,孙虹,Richard Salvi..氨基糖苷类抗生素对耳蜗螺旋神经节的损害作用[J].中华耳科学杂志,2015,(1):37-42,6.基金项目
国家自然科学基金面上项目81170912；国家教育部博士点专项基金（博导类），编号20110162110007 （）
