中华耳科学杂志Issue(1)：49-56,8.DOI:10.3969/j.issn.1672-2922.2015.01.009
听神经病实验动物模型
Experimental Animal Models with features of Auditory Neuropathy
摘要
Abstract
Clinically, auditory neuropathy is characterized by normal or near normal otoacoustic emissions, audiomet⁃ric thresholds and cochlear microphonic potentials, but abnormal or absent auditory brainstem response waveforms and cen⁃tral auditory processing deficits such as poor speech perception, difficulty hearing in noise and poor temporal processing. The pathological changes underlying auditory neuropathy are believed to originate from the inner hair cells-auditory nerve system and may involve missing inner hair cells, synaptic dysfunction between the inner hair cell and type I auditory neurons, and de⁃generation or demyelination of auditory nerve fibers that project to the cochlear nucleus. This paper describes various experi⁃mental animal models that have been developed to mimic certain aspects of auditory neuropathy. These include animal mod⁃els with missing inner hair cell induced by deletion of the Slc19a2 or Ggt1 genes, degeneration of type I afferent terminals by glutamate excitotoxicity, demyelination of auditory nerve fibers by adriamycin, hyperbilirubin and glycerin, surgical compres⁃sion of the auditory nerve, autoimmune diseases, and carboplatin-induced degeneration of inner hair cells and type I auditory nerve fibers in chinchillas. These different experimental models have provided unique insights of auditory function and simu⁃late different clinical manifestations and pathological features of auditory neuropathy.关键词
听神经病/实验动物模型Key words
Auditory neuropathy/Eexperimental animal model分类
医药卫生引用本文复制引用
李鹏,丁大连,曾祥丽,Richard Salvi..听神经病实验动物模型[J].中华耳科学杂志,2015,(1):49-56,8.基金项目
广东省科技计划项目2011B031800359；国家外国专家局审批类项目CG2013440003；国家自然科学基金Grant No.81300819 （）
