中华耳科学杂志Issue(1)：57-63,7.DOI:10.3969/j.issn.1672-2922.2015.01.010
钴的神经毒性及耳毒性
Neurotoxicity and Ototoxicity of Cobalt
摘要
Abstract
Cobalt is an important essential element that is required for the synthesis and functional activity of vitamin B12. Therefore, cobalt is necessary for life. However, if intracellular concentrations of cobalt are excessive due to occupation⁃al exposure, dietary intake, or endogenous exposure from cobalt-chromium implants, it can also lead to a severe disorder, called metallosis characterized by sensorineural hearing loss, nervous tinnitus, visual impairment, cognitive impairment, pe⁃ripheral neuropathy, cardiomyopathy, heart failure, thyroid problems, skin rashes, etc. Among these toxicities by cobalt, senso⁃ry deafness and optic atrophy are the most noticeable symptoms. The toxic mechanisms of cobalt mainly involve oxidative stress, hypoxic injury and mitochondrial-induced apoptosis. Therefore, animal models of cobalt intoxication are applicable to research examining an imbalance in oxidation/antioxidation equilibrium, intracellular hypoxia, and mitochondria initiated apoptotic pathways, especially in the auditory, vision and nervous systems.关键词
钴/耳毒性/神经毒性Key words
Cobalt/Ototoxicity/Neurotoxicity分类
医药卫生引用本文复制引用
李鹏,丁大连,曾祥丽,Richard Salvi,Jerome A. Roth..钴的神经毒性及耳毒性[J].中华耳科学杂志,2015,(1):57-63,7.基金项目
广东省科技计划项目2011B031800359；National Insti-tute for Occupational Safety and HealthR01 OH010235；国家自然科学基金 （）
