中华耳科学杂志Issue(1)：92-96,5.DOI:10.3969/j.issn.1672-2922.2015.01.017
阳离子聚合物纳米基因载体在内耳的应用进展
Prospects of Application of Cationic Polymer Nanoparticle Gene Vectors in Inner Ear
摘要
Abstract
Due to the unique anatomical and physiological features of the cochlea, systemic drug/gene therapy is diffi⁃cult to achieve effective local concentrations in the inner ear. Therefore,research on local drug/gene in the inner ear has be⁃come a new hotspot. Selecting an appropriate vector for local drug/gene therapy is the key point. Compared with virus vec⁃tor, polymer nanoparticle vector has the advantages of carrying low toxicity and no immunogenicity, and being easy to modify and acquire with high transporting capability, making it a improved option as a vector for drug/gene delivery to the inner ear. This paper summarizes the characteristics of cationic polymers and their superiority as drug/gene vector. Furthermore, it al⁃so reviews the application of cationic polymers in the inner ear, and provides guidance for potential transition towards drug/gene therapies bb for inner ear disorders.关键词
耳聋/阳离子聚合物/纳米载体Key words
Hearing loss/Cationic polymers/Nnanoparticle vector分类
医药卫生引用本文复制引用
王方园,吴南,陈正一,杨仕明..阳离子聚合物纳米基因载体在内耳的应用进展[J].中华耳科学杂志,2015,(1):92-96,5.基金项目
国家重大科学研究计划干细胞项目（2012CB967900）；国家973计划重大科学问题导向项目（2011CBA01000）；863青年科学家项目 （）
国家科技部新药创制重大专项（2014ZX09J14101-06C）；国家自然科学基金项目 （）
