中华耳科学杂志Issue(1)：141-144,4.DOI:10.3969/j.issn.1672-2922.2015.01.027
白噪声暴露前后豚鼠听觉功能的检测
Detection of Guinea Pigs’Hearing Functions before and after White Noise Exposure
摘要
Abstract
Objective Using different techniques to detect guinea pigs’hearing functions before and after white noise exposure,to study the effects of 120 dB SPL white noise on hearing in guinea pigs, as an animal model for hearing research in guinea pigs. Methods In the noise exposure condition of 120 dBSPL white noise, to compare the auditory brainstem response (ABR), distortion product otoacoustic emission (DPOAE) and electrically evoked auditory brainstem response (eABR) were compared between 20 guinea pigs exposed to white noise at 120 dB SPL and 20 normal control guinea pigs. Results ABR thresholds, DPOAE amplitudes and eABR thresholds were significantly different between the noise exposed guinea pigs and normal control guinea pigs (p<0.05). Conclusion White noise at 120 dB SPL can consistently induced hearing loss in guin⁃ea pigs, which can serve as an animal model for studying hearing and hearing loss.关键词
豚鼠/噪声性聋/听性脑干反应/畸变产物耳声发射/电刺激ABRKey words
Guinea pig/Noise-induced hearing loss/ABR/DPOAE/eABR分类
医药卫生引用本文复制引用
张纪帅,陈星睿,吴军,韩维举..白噪声暴露前后豚鼠听觉功能的检测[J].中华耳科学杂志,2015,(1):141-144,4.基金项目
国家自然科学基金面上项目 （）
