中华骨质疏松和骨矿盐疾病杂志Issue(1)：21-26,6.DOI:10.3969/j.issn.1674-2591.2015.01.005
住院老年患者骨骼肌减少与骨密度的关系
Relationship between skeletal muscle loss and bone mineral density in hospitalized elderly people
摘要
Abstract
Objective To investigate the relationship between appendicular-skeletal muscle mass ( ASMM ) , relative skeletal muscle index (RSMI), and bone mineral density (BMD) in hospitalized elderly people, and the relation-ship between skeletal muscle loss and osteoporosis , exploring new ideas for the prevention of osteoporosis and fragility frac-ture.Methods Height, weight, body mass index (BMI), ASMM, RSMI, BMD, and T-sore at different sites, fat%were evaluated in 562 elderly from The First Affiliated Hospital of Chongqing Medical University , using dual-energy X-ray absorptiometry ( DXA) .Pearson’s correlation analysis was used to estimate associations between different variables about patient’s general characteristics , and relationships between skeletal muscle loss , osteoporosis and fragility fracture were es-timated by logistic regression analysis .Results RSMI had significantly positive correlation with BMD in both genders ( Lumbar:male r=0.203 , P<0.01 , female r=0.165 , P<0.01;Hip:male r=0.253 , P<0.01 , female r=0.225 , P<0.01 ) , and also had highly positive correlation with BMI ( male r=0.777 , P<0.01 , female r=0.791 , P<0.01 );BMD had significantly positive correlation with BMI ( Lumbar:male r=0.319 , P<0.01 , female r=0.236 , P<0.01;Hip:male r=0.199 , P<0.01 , female r=0.211 , P<0.01 ) .The prevalence of osteoporosis and fragility fracture were significantly higher in elderly women patients , while men suffered more skeletal muscle loss .Men with skeletal muscle loss had a higher risk of osteoporosis in the elderly (β=0.774 , P=0.002 , OR=2.168 ) , but this relationship does not exist in women ( P>0.05 ) .Conclusions In the elderly , bone and muscle had close relationship;osteoporosis and skel-etal muscle loss had obvious gender differences:significantly positive correlation in men , and no relationship in women . Fragility fracture had close relationship with both osteoporosis and skeletal muscle loss .Raising muscle mass is significant for the prevention of osteoporosis and fragility fracture .关键词
骨骼肌指数/骨密度/骨骼肌减少/骨质疏松/脆性骨折Key words
relative skeletal muscle index/bone mineral density/skeletal muscle loss/osteoporosis/fragility fracture分类
医药卫生引用本文复制引用
李喜凤,赵柯湘,徐凌杰,邓永涛,程雯,吕洋,肖谦..住院老年患者骨骼肌减少与骨密度的关系[J].中华骨质疏松和骨矿盐疾病杂志,2015,(1):21-26,6.基金项目
国家临床重点专科建设项目［国卫办医函（2013）544号］；重庆市科技攻关（应用技术研究类）重点项目 （）
