中华肝脏外科手术学电子杂志Issue(1)：31-34,4.DOI:10.3877/cma.j.issn.2095-3232.2015.01.009
TACE联合射频消融治疗结肠癌肝转移患者的临床疗效
Clinical efficacy of TACE combined with radiofrequency ablation in the treatment of liver metastasis of colon cancer
摘要
Abstract
Objective To investigate the clinical efifcacy of transcatheter arterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) in treatment of liver metastasis of colon cancer. Methods A total of 68 patients with liver metastasis of colon cancer in the Sixth Affiliated Hospital of Sun Yat-sen University from June 2007 to May 2011 were enrolled in this prospective study. The informed consents of all patients were obtained and local ethical committee approval had been received. There were 43 males and 25 females with a mean age of (59±4) years old. The patients were divided into RFA group and Control group with 34 cases in each group according to random number table method. Patients in both groups underwent TACE ifrstly and patients in RFA group underwent RFA 3 weeks after TACE treatment. Cluster of differentiation (CD) 3+, CD4+, CD8+positive cell percentage and CD4+/CD8+ratio were deifned by flow cytometry before and after treatments in two groups. The tumor diameter after treatments and general efifcacy were observed. The patients were followed up and the tumor recurrence and survival of the patients were observed. The comparisons of tumor diameter and immune function between two groups were conducted using t test. The comparison of efifcacy between two groups was conducted using rank sum test. The survival analysis was conducted using Log-rank test and Z test. Results The CD4+, CD8+percentage and CD4+/CD8+ratio were (42±4)%, (13±3)%, 2.9±0.9 in RFA group after treatment and were (33±4)%, (17±3)%, 2.3±0.9 in Control group, where signiifcant differences were observed (t=5.483,-6.488, 9.321;P<0.05). The tumor diameter in RFA group after treatment [(0.9±0.1) cm] was significantly smaller than that in Control group [(1.9±0.2) cm] (t=-4.573, P<0.05). The total effective rate in RFA group was 62%(21/34) and was 35%(12/34) in Control group. The treatment efifcacy of RFA group was better than that of Control group (Z=4.769, P<0.05). The 2-, 3-year survival rates in RFA group (38.2%, 23.5%) were significantly higher than those in Control group (14.7%, 5.9%) (Z=4.836, 4.221; P<0.05). Conclusions TACE combined with RFA is a safe and effective regimen in treating liver metastasis of colon cancer. The efifcacy may be associated with the improvement of the body’s immune function.关键词
结肠肿瘤/肝肿瘤/肿瘤转移/消融技术/化学栓塞,治疗性Key words
Colonic neoplasms/Liver neoplasms/Neoplasm metastasis/Ablation techniques/Chemoembolization, therapeutic引用本文复制引用
何科,王晶,徐丽南,瞿虎,江春强,柯嘉,俞建东,苏中振,尧冰..TACE联合射频消融治疗结肠癌肝转移患者的临床疗效[J].中华肝脏外科手术学电子杂志,2015,(1):31-34,4.基金项目
广东省科技计划项目 （）
