中华临床免疫和变态反应杂志Issue(2)：95-100,6.DOI:10.3969/j.issn.1673-8705.2014.02.002
螨制剂舌下免疫治疗对单一和多重致敏变应性鼻炎的疗效评估
Clinical Evaluation of Efficacy of Sublingual Immunotherapy with Dermatophagoides farinae Extract among Monosensitized and Polysensitized Patients with Allergic Rhinitis
摘要
Abstract
Objective To investigate the potential difference of efficacy of sublingual immunotherapy between monosensitized and polysensitized allergic rhinitis patients. Methods Clinical efficacy of sublingual immunotherapy was evaluated among monosensitized patients and polysensitized patients who were treated with sublingual immunotherapy more than 1 year.20 cases of monosensitized patients who were sensitized to house dust mite and 30 cases of polysensitized patients who were sensitized to house dust mites and other allergens were involved in this study.The phylogenetic tree of the allergenic components of house dust mite and other allergens used in skin prick test was constructed.Results Among 50 cases involved in this study,evident effect shown in 22 cases,moderate effect in 1 5 cases,and inefficacy in 1 3 cases.The total effective rate was 74%.Of all 50 patients with allergic rhinitis,30 cases (60%)were polysensitized patients.The top three kinds of allergens with the highest positive rate were cockroach (83%),winter pollen (70%),and silk (63%)respectively.There was no significant difference statistically between the efficacy of sublingual immunotherapy in dust mite-monosensitized patients and polysensitized patients with sublingual immunotherapy more than one year.Conclusions There was no difference between the efficacy of sublingual immunotherapy with Dermatophagoides farinae drops in house dust mite-monosensitized and polysensitized allergic rhinitis patients.Sublingual immunotherapy using Dermatophagoides farinae drops can be used as conventional treatment in polysensitized patients.关键词
尘螨/变应性鼻炎/舌下脱敏治疗/疗效分析Key words
host-dust-mite/allergic-rhinitis/sublingual-immunotherapy/efficacy-evaluation分类
医药卫生引用本文复制引用
许晨霞,张妙莲,邹泽红,何颖,伍秋容,赖荷,陶爱林..螨制剂舌下免疫治疗对单一和多重致敏变应性鼻炎的疗效评估[J].中华临床免疫和变态反应杂志,2014,(2):95-100,6.基金项目
国家科技重大专项重大课题基金（2011 ZX08011-005），广州市科技攻关专项项目基金（201300000159），呼吸疾病国家重点实验室（广州医科大学）课题研究基金 （）
