中华临床免疫和变态反应杂志Issue(1)：55-60,6.DOI:10.3969/j.issn.1673-8705.2015.01.011
新生儿红斑狼疮心脏受累
Pathogenesis and Treatment of Neonatal Lupus Erythematosus with Cardiac Involvement
李霞 1张丽丽 1赵岩1
作者信息
- 1. 中国医学科学院 北京协和医学院 北京协和医院风湿免疫科，风湿免疫病学教育部重点实验室，北京 100730
- 折叠
摘要
Abstract
Neonatal lupus erythematosus (NLE)is a passively acquired autoimmune disease associated with maternal anti-Ro/SSA,anti-SSB/La and anti U1RNP antibodies,of which fetal heart involvement is the most serious clinical manifestations.The molecular mechanisms are not fully understood, but several targets for the maternal autoantibodies in the fetal heart have been suggested.Recent studies also indicate that environmental factors and fetal susceptibility genes determine whether an autoantibody-exposed fetus will develop congenital heart block (CHB)or not.Prenatal application of fluorinatedcorticosteroids,hydroxychloroquine,intravenous immunoglobulin (IVIG),and plasmapheresis have been under investigation,but the results are controversial.In this article,we reviewed the advances in the pathogenesis and treatment of NLE with cardiac involvement in order to pursue early interventions.关键词
新生儿红斑狼疮/心脏受累/发病机制/治疗Key words
lupus erythematosus,neonatal/cardiac involvement/pathogenesis/treatment分类
医药卫生引用本文复制引用
李霞,张丽丽,赵岩..新生儿红斑狼疮心脏受累[J].中华临床免疫和变态反应杂志,2015,(1):55-60,6.
